CN EN

付远辉

职称:副教授

学历:研究生

学位:博士

电话:010-51684351-806

邮箱:yhfu@bjtu.edu.cn

教育背景

1997年毕业于武汉冶金科技大学(现武汉科技大学)

2004年毕业于郑州大学,获得硕士学位

2009年6月毕业于中国疾病预防控制中心病毒病预防控制所,获得博士学位。






工作经历


2009年7月至今 北京交通大学理学院,一直从事肿瘤免疫治疗和疫苗的研究,作为先后主持及参与国家自然科学基金、 “十四五”国家重点研发计划、“十二五”传染病重大专项、“十二五”新药创制重大专项等项目多项,已在国内外学术期刊发表论文30余篇,获得中国发明专利授权9项。

研究和招生方向包括:

(1)肿瘤免疫治疗:溶瘤疫苗和溶瘤腺病毒药物在肿瘤免疫治疗中的应用研究

(2)载体疫苗:以ChAd68、ChAd63、Ad26及h/bPIV3为载体开发相关疫苗






研究方向
  • 生物化学与分子生物学
  • 细胞生物学
招生专业
  • 生物学硕士
科研项目

(1)“十四五”国家重点研究计划--任务,新型病毒载体与减毒疫苗研究和应用(项目,2023YFC2307900)---建立规模化符合GMP要求的制备工艺技术(课题,2023YFC2307904)---人血清稀有型腺病毒载体呼吸道合胞病毒疫苗工艺优化和放大(任务),2023/12-2026/11,58.5万,主持

(2)国家自然科学基金“面上”项目,32370994,可克服免疫逃逸的新型呼吸道合胞病毒减毒活疫苗免疫效力研究,2024/01-2027/12,65万元,主持

(3)北京-海淀联合基金,L222074,人呼吸道合胞病毒腺病毒载体黏膜疫苗免疫效力及机制研究,2023/01-2025/12,29.3万元,主持

(4)自然科学横向项目,V23L00120,RSV单克隆抗体中和活性检测,2023/05-2023/07,5.58万,主持

(5)自然科学横向项目,V22L00120,单克隆抗体抗RSV中和活性检测,2022/07-2023/07,18.6万,主持

(6)自然科学横向项目,V22L00130,细胞上清抗RSV中和活性检测,2022/07-2023/03,7.25万,主持

(7)自然科学横向项目,S21L00170,呼吸道合胞病毒单克隆抗体活性检测,2021/09-2022/05,10万,主持

(8)自然科学横向项目,S21L00160,RSV单克隆抗体的中和活性检测,2021/08-2022/08,20万,主持

(9)联合研发项目,KSL18015530,重组腺病毒初免-加强型呼吸道合胞病毒疫苗,2018/05-2038/05,2000万元,参加

(10)国家自然科学基金“面上”项目,81771777,人呼吸道合胞病毒复制缺陷型活疫苗与减毒活疫苗:免疫原性及安全性的比较研究,2018/01-2021/12,55万元,参加

(11)校基本科研业务费,2014JBM123,呼吸道合胞病毒病毒样颗粒黏膜免疫评价,2014/01-2014/12,8万元,主持

(12)国家重大专项(民口),2013ZX10004601,基于化学基因组学的病原诊治生物标志物高通量筛选平台,2013/01-2015/12,1578万元,参加

(13)国家重大专项(民口),2013ZX09103003-011,呼吸道合胞病毒减毒活疫苗研制,2013/01-2015/12,132.32万元,参加

(14)校人才基金,2012RC050,呼吸道合胞病毒病毒样颗粒制备及其免疫保护作用研究,2013/01-2014/12,2万元,主持

(15)中国博士后科学基金,20100470196,靶向树突状细胞的呼吸道合胞病毒核酸疫苗的免疫效果研究,2010/09-2011/07,3万元,主持

(16)校基本科研业务费,2009JBM104,以抗DEC205单链抗体靶向树突状细胞提高腺病毒载体疫苗免疫效果,2010/01-2011/12,5万元,主持

(17)国家自然科学基金面上项目,30972604,提高以腺病毒载体为基础的呼吸道合胞病毒疫苗安全性和有效性的方法研究,2010/01-2012/12,32.0万元,参加





教学工作
论文/期刊
  • Jie‑Mei Yu, Yuan‑Hui Fu, Xiang‑Lei Peng, Yan‑Peng Zheng & Jin‑Sheng He. Genetic diversity and molecular evolution of human respiratory syncytial virus A and B, Scientific Reports (2021) 11:12941, https://doi.org/10.1038/s41598-021-92435-1

    Li-Nan Wang, Xiang-Lei Peng, Min Xu, Yuan-Bo Zheng, Yue-Ying Jiao, Jie-Mei Yu, Yuan-Hui Fu, Yan-Peng Zheng, Wu-Yang Zhu, Zhong-Jun Dong, Jin-Sheng He, Evaluation of the Safety and Immune Efficacy of Recombinant Human Respiratory Syncytial Virus Strain Long Live Attenuated Vaccine Candidates. Virologica Sinica, 2021, DOI: 10.1007/s12250-021-00345-3

    Minghua Wang, Guoning Zhang, Jianyuan Zhao, Ningning Cheng, Yujia Wang, Yuanhui Fu, Yanpeng Zheng, Juxian Wang, Mei Zhu, Shan Cen, Jinsheng He, Yucheng Wang. Synthesis and antiviral activity of a series of novel quinolone derivatives as anti-RSV or anti-IAV agents. European Journal of Medicinal Chemistry, 214 (2021) 113208, DOI: 10.1016/j.ejmech.2021.113208

    Jie-Mei Yu, Li-Shu Zhang, Yuan-Hui Fu, Feng-Min Ji, Han-Li Xu, Jia-Qiang Huang, Xiang-Lei Peng, Yan-Peng Zheng, Ying Zhang and Jin-Sheng He. Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2. Evolutionary Bioinformatics, 2020, Volume 16: 1–6, DOI: 10.1177/1176934320954870

    Guo-Ning Zhang, Qiang Li, Jianyuan Zhao, Xuandi Zhang, Zhuxin Xu, Yujia Wang, Yuanhui Fu, Qi Shan, Yanpeng Zheng, Juxian Wang, Mei Zhu, Ziqiang Li, Shan Cen, Jinsheng He, Yucheng Wang. Design and synthesis of 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides as novel dual inhibitors of respiratory syncytial virus and influenza virus A. European Journal of Medicinal Chemistry, 186 (2020) 111861

    Yuan-Hui Fu; Zhu-Xin Xu; Nan Jiang; Yan-Peng Zheng; Marie-Anne Rameix-Welti; Yue-Ying Jiao; Xiang-Lei Peng; Ye Wang; Jean-Francois Eleouet; Shan Cen; Jinsheng He. High-throughput screening of active compounds against human respiratory syncytial virus. Virology, 535 (2019) 171–178

    Yao Ma, Yue-Ying Jiao, Yun-Zhou Yu, Nan Jiang, Ying Hua, Xiu-Juan Zhang, Yuan-Hui Fu, Xiang-Lei Peng, Yan-Peng Zheng, Larry J. Anderson, and Jin-Sheng He. A Built-In CpG Adjuvant in RSV F Protein DNA Vaccine Drives a Th1 Polarized and Enhanced Protective Immune Response. Viruses 2018, 10, 38; doi:10.3390/v10010038.

    Min Xu, Yue-Ying Jiao, Yuan-Hui Fu, Nan Jiang, Yuan-Bo Zheng, Yi-Fei Yan, Mei Zhang, Yan-Peng Zheng, Wu-Yang Zhu, Xiang-Lei Peng, Jin-Sheng He. Construction and characterization of a recombinant human respiratory syncytial virus encoding enhanced green fluorescence protein for antiviral drug screening assay. BioMed Research International, Volume 2018, Article ID 8431243, 8 pageshttps://doi.org/10.1155/2018/8431243

    Yue-Ying Jiao, Yuan-Hui Fu, Yi-Fei Yan, Ying Hua, Yao Ma, Xiu-Juan Zhang, Jing-Dong Song, Xiang-Lei Peng, Jiaqiang Huang, Tao Hong, Jin-Sheng He. A single intranasal administration of virus-like particle vaccine induces an efficient protection for mice against human respiratory syncytial virus. Antiviral Research, 2017144 57-69. 

    Ying Hua, Yue-Ying Jiao, Yao Ma, Xiang-Lei Peng, Yuan-Hui Fu, Xiu-Juan Zhang, Yuan-Bo Zheng, Yan-Peng Zheng, Tao Hong, Jin-Sheng He. Enhanced humoral and CD8 + T cell immunity in mice vaccinated by DNA vaccine against human respiratory syncytial virus through targeting the encoded F protein to dendritic cells. International Immunopharmacology, 2017, dx.doi.org/10.1016/j.intimp.20174662-69

    Yuan-Hui Fu, Ya-Ru Liu, Yan-Peng Zheng, Nan Jiang, Yue-Ying-Jiao, Yao Ma, Wei Li, Xiang-lei Peng, Jinsheng He. An RNA polymerase I-driven human respiratory syncytial virus minigenome as a tool for quantifying virus titers and screening antiviral drug. Chinese Chemical Letters, 2017, 28: 131-135 

    Ying Hua, Yue-Ying Jiao, Yao Ma, Xiang-Lei Peng, Yuan-Hui Fu, Yan-Peng Zheng, Tao Hong, Jin-Sheng He. DNA Vaccine Encoding Central Conserved Region of G Protein Induces Th1 Predominant Immune Response and Protection from RSV Infection in Mice. Immunology Letters, 201617995-101

    Yuan-Hui Fu, Yue-Ying Jiao, Jinsheng He, Gui-Yun Jiang, Wei Zhang Yao, Ma Ying Zhang, Chang-Xin Shi, Xiang-Lei Peng, Tao Hong, Yi-Fei Yan. Sublingual administration of a helper-dependent adenoviral vector expressing the codon-optimized soluble fusion glycoprotein of human respiratory syncytial virus elicits protective immunity in mice. Antiviral Research 105 (2014), 72-79, DOI: 10.1016/j.antiviral.2014.02.003

    Yuan-hui Fu, Jin-sheng He, Wei Qiao, Yue-ying Jiao, Ying Hua, Ying Zhang, Xiang-Lei Peng, and Tao Hong. Intranasal immunization with a helper-dependent adenoviral vector expressing the codon-optimized fusion glycoprotein of human respiratory syncytial virus elicits protective immunity in BALB/c mice. Virol J, 2013, 10:183. DOI: 10.1186/1743-422X-10-183

    Zheng YP, Tang Y, Fu YH, He JS,Wang XB, Hong T. Purification of human respiratory syncytial virus fusion glycoprotein. Protein Expr. Purif, 2012, 81(1): 115-118

    Yuan-hui Fu, Rui-juan Lv, Li-ri Jin, Qiang Lu, Xiao-qiu Shao, Jin-sheng He, Li-wen Wu, Li-shu Zhang, Hong-gang Hu. Association of apolipoprotein E polymorphisms with temporal lobeepilepsy in a Chinese Han population. Epilepsy Res, 2010, 91(2-3): 253-259

    Yuan-hui Fu, Jin-sheng He, Xiao-bo Wang, Xian-Xian Zheng, Qiang Wu, Can Xie, Wei Wei, Qian Tang, Jing-Dong Song, Jian-Guo Qu, Tao Hong. A prime–boost vaccination strategy using attenuated Salmonella typhimurium and a replication-deficient recombinant adenovirus vector elicits protectiveimmunity against human respiratory syncytial virus. Biochem Biophys Res Commun, 2010, 395(1): 87-92

    Yuanhui Fu, Jinsheng He, Xianxian Zheng, Xiao-bo Wang, Can Xie, Chang-xin Shi, Mei Zhang, Qian Tang, Wei Wei, Jian-guo Qu and Tao Hong. Intranasal vaccination with a helper-dependent adenovirus vector enhances transgene-specific immune responses in BALB/c mice. Biochem Biophys Res Commun, 2010, 391(1): 857-861

    Yuanhui Fu, Jinsheng He, Xianxian Zheng, Qiang Wu, Mei Zhang, Xiaobo Wang, Yan Wang, Can Xie, Qian Tang, Wei Wei, Min Wang, Jingdong Song, Jianguo Qu, Ying Zhang, Xin Wang, Tao Hong. Intranasal Immunization with a Replication-Deficient Adenoviral Vector Expressing the Fusion Glycoprotein of Respiratory Syncytial Virus Elicits Protective Immunity in BALB/c Mice. Biochem Biophys Res Commun, 2009, 381(4):528-532



  • 专著/译著
    专利

    1发明人:付远辉;何金生;黄蕾;虞结梅;彭向雷;郑妍鹏,中国发明专利:两种表达水痘-带状疱疹病毒的 gE 蛋白的重组腺病毒及应用,专利号:ZL 202111536306.5,授权公告日:20231031日。

    2、发明人:何金生;付远辉;刘美琴;彭向雷;郑妍鹏;黄蕾,中国发明专利:呼吸道合胞病毒全长融合前融合糖蛋白核苷酸序列、 重组腺病毒载体及其应用产品,专利号:ZL 202010863762.X,授权公告日:20220930日。

    3、发明人:何金生;付远辉;彭向雷;郑妍鹏,中国发明专利:一种共表达呼吸道合胞病毒融合前蛋白和黏附糖蛋白的复制缺陷型腺病毒载体疫苗,专利号:ZL 202010864874.7,授权公告日:20220905日。

    4、发明人:何金生;杜琳;付远辉;朱卫华;彭向雷;高博;郑妍鹏;刘美琴, 中国发明专利:一种针对呼吸道合胞病毒感染的组合疫苗,专利号:ZL 202010863764.9,授权公告日:20220615日。

    5、发明人:何金生;马尧;付远辉;彭向雷;郑妍鹏,中国发明专利:一种呼吸道合胞病毒融合前F蛋白及其应用,专利号:ZL 201910337141.5,授权公告日:20210910日。

    6、发明人:何金生;王玉成;付远辉;张国宁;徐竹欣;李强;郑妍鹏;王菊仙;彭向雷;白晓光,中国发明专利:一类3-位官能团化的N(O,S)-杂茚类衍生物及其在抗呼吸道合胞病毒中的应用,专利号:ZL 201810109813.2,授权公告日:20200924日。

    7、发明人:何金生;彭向雷;许敏;付远辉,中国发明专利:基于反向遗传学构建的RSV反基因组质粒及其应用,专利号:201710574632.2,授权公告日:20200305日。

    8、发明人:何金生;付远辉;彭向雷;郑研鹏;姜男;许敏,中国发明专利:一种呼吸道合胞病毒药物的高通量筛选方法和应用,专利号:ZL201710244050.8,授权公告日:20190704日。

    9、发明人:何金生;付远辉;焦月盈;洪涛,中国发明专利:一种呼吸道合胞病毒病毒样颗粒及其制备方法和应用,专利号:ZL 201310667523.7,授权公告日:20160824日。




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