CN EN

ZHANG Jinhua

Professional title:Professor

Office No.:18910876157

Email:zhangjh@bjtu.edu.cn

Education

2003-2006   Physiology, China Agricultural University, Beijing, China, Ph.D.  

2000-2003   Zoology, Northeast Normal University, Changchun, China, M.S.

1996-2000  Biology, Jilin Normal University, Siping, China, B.S.

Career/Academic Appointments: 

2019-present Professor, College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing

2015–2017  Visiting Scientist, Molecular Cancer Epidemiology, The University of Texas, MD Anderson Cancer Center, Houston, TX

2014-2019 Associate Professor, College of Life Science and Bioengineering, Beijing  Jiaotong University 

2010-2014  Assistant Professor, Associate Professor, Institute of Biophysics, Chinese Academic of Sciences

2006-2010 Post Doctor, Institute of Biophysics, Chinese Academic of Sciences,Beijing

Professional Experience

Dr. Zhang Jinhua, Professor, Institute of life sciences and Bioengineering, Beijing Jiaotong University. From July 2006 to June 2014, she worked as a postdoctoral and associate researcher in the research group of researcher Qin Zhihai of Institute of Biophysics, Chinese Academy of Sciences. In July 2014, she joined the team of academician Chen Zhinan of the Institute of life sciences and bioengineering of Beijing Jiaotong University.

Her research interest is tumor microenvironment and tumor immunity.  She has published 28 SCI papers in cancer research, Journal of Hepatology, cell research, oncoimmunology and other journals. Presided over 6 National Natural Science Foundation projects and 1 sub project of the national "973" Program.

Research Field

Tumor microenvironment

The role and molecular mechanism of different stromal cells in tumor microenvironment, such as fibroblasts and macrophages, in the development of lung cancer, colon cancer and liver cancer. By using a variety of transgenic and gene knockout mice, with different transplanted tumor models and chemical induction models, combined with clinical samples studies:

(1) The mechanism of inflammatory factors in the growth and metastasis of lung cancer.

(2) The molecular mechanism of the development of colitis and colon cancer

(3) The molecular mechanism of the development of liver fibrosis, alcoholic liver, fatty liver, and liver cancer.

Projects

  1. National Natural Science Foundation of China (Major Program, Grant No. 81972689); The role of Toll-like receptor in fibroblasts in macrophage regulation and colitis-associated tumorigenesis; PI, 2020/01-2023/12; 550000 ¥
  2. National Natural Science Foundation of China (Major Program, Grant No.81772497); The role of S100A4 on autophagy  in lung tumor development; PI, 2018/01-2021/12; 550000¥
  3. National Program on Key Basic Research Project (973 Program)"Inflammation-cancer biological signal interaction regulation of cancer progression and molecular mechanisms of suppressive therapy" project (2015CB553700), Subproject leader; 2015/01-2019/12;1155000¥
  4. Beijing Municipal Natural Science Foundation (Major Program); The role of Fibroblasts in Inflammation Regulation and Colon Carcinogenesis; PI, 2016/01-2018/12; 180000¥
  5. Emergency Management Project of National Natural Science Foundation of China; The role of S100A4 in colitis-associated tumorigenesis; PI, 2016/01-2016/12; 10000¥
  6. Basic scientific research  expenses of Beijing Jiaotong University ; 2015JBM095; The role of S100A4 positive cells in chronic inflammation and tumorigenesis; PI, 2015/01-2016/12;70000¥ 
  7. Talent Fund of Beijing Jiaotong University; 2014RC022; The Role of Fibroblasts in the Transition of Inflammatory Carcinoma; PI, 2014/9-2016/8; 150000¥        
  8. National Natural Science Foundation of China (Major Program, Grant No.81370543); The role of S100A4 positive cells in liver fibrosis; PI, 2014/01-2017/12; 700000¥                              
  9. National Natural Science Foundation of China (Innovation Fund, Grant No.81141095); The role of Toll-like receptor signaling of immune cells regulates inflammation and tumorigenesis; PI, 2012/01-2012/12; 100000¥
  10. National Natural Science Foundation of China (Youth Fund, Grant No.30700287); The role of  fibroblasts in tumorigenesis and development; PI, 2008/01-2010/12; 170000¥
  11. Postdoctoral Science Foundation of Institute of Biophysics, Chinese Academy of Sciences; The role of fibroblasts in tumorigenesis; PI, 2008/01-2008/12; 64000¥
  12. China Postdoctoral Science Foundation; The role of IL-4 regulating the formation of new blood vessels in tumorigenesis; PI, 2006/01-2006/12; 30000¥

Teaching Courses

The Science of Biology

Laboratory Animal Sciences

Molecular immunology

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