CN EN

HUANG Jiaqiang

Professional title:Professor

Office No.:10-51684348

Email:jqhuang@bjtu.edu.cn

Education

1997 Ph.D., Immunology, Huazhong University of Science & Technology, Hubei, China

1993 M.S. Med, Immunology, Huazhong University of Science & Technology, Hubei, China 

1986  MD., Clinical Medicine, Henan University School of Medicine, Henan, China         

Professional Experience

The primary interests of Dr. Huang are immunity and epigenetics in relation to tumor biomarker development. His work is focused on the epigenetic regulation of gene expression and its dysregulation in cancer. Dr. Huang obtained his Ph.D. in 1997 from the Huazhong University of Science & Technology. After training as a postdoctoral fellow with professor Dalong Ma at Beijing University, he was then a visiting Fellow, and later a scientist at the laboratory of Molecular Immunoregulation of Dr. Kathrin Muegge at NCI-Frederick, NIH. He then joined Johns Hopkins University School of Medicine as a faculty member and a Research Associate in the laboratory of professor Leiping Chen. He later joined Qiagen-Frederick in 2007 as a senior scientist. In 2011, he was appointed to the Professor of the College of Life Sciences and Bioengineering at the Beijing Jiaotong University.

Research Field

Cancer epigenetics, Molecular immunology

Projects

Epigenetic regulation of myeloid zinc-finger 1 interacting with metallothionein 2A in relation to the sensitivity of chemotherapy of gastric cancer. National Science Foundation of China (NSFC Grant No. 81872021)

Teaching Courses

Essential Biology, Epigenetics, Cellular and Molecular Immunology 

Paper

  1. Chen K#, Yoshimura T, Yao X, Gong W, Huang J, Dzutsev AK, McCulloch J, O'hUigin C, Bian XW, Trinchieri G, Wang JM*. Distinct contributions of cathelin-related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis. J Pathol. 021,253 (3):339-350.
  2. Lin S#, Tian C, Li J, Liu B, Ma T, Chen K, Gong W, Wang JM, Huang J*. Differential Mucin 22 Expression by Epigenetic Alterations in Human Lung Squamous Cell Carcinoma and Adenocarcinoma. Oncol Rep.. 2021,45(5):78-.
  3. Chen K#, Yoshimura T, Gong W, Tian C, Huang J, Trinchieri G, Wang JM*. Requirement of CRAMP for mouse macrophages to eliminate phagocytosed E. coli through an autophagy pathway. J Cell Sci . 2021,134(5):1-11.
  4. Liang W#, Peng X#, Li Q, Wang P, Lv P, Song Q, She S, Huang S, Chen K, Gong W, Yuan W, Thovarai V, Yoshimura T, O'huigin C, Trinchieri G, Huang J, Lin S, Yao X, Bian X, Kong W, Xi J, Wang JM*, Wang Y*. FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis. Nat Commun. 2020,11(1):5912.
  5. Tian C#, Chen K, Gong W, Yoshimura T, Huang J, Wang JM*. The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer. Technol Cancer Res Treat. Technol Cancer Res Treat. 2020,19:11-19.
  6. Pan Y#, Wang X#, He Y#, Lin S, Zhu M, Li Y, Wang J, Wang J, Ma X, Xu J, Yang L, Yang G, Huang J*, Lu Y*, Sheng J*. Tumor suppressor ATP4B serve as a promising biomarker for worsening of gastric atrophy and poor differentiation. Gastric Cancer. 2020,24(2):314-326.
  7. Zhang M#, Gao JL#, Chen K, Yoshimura T, Liang W, Gong W, Li X, Huang J, McDermott DH, Murphy PM, Wang X, Wang JM*.  A Critical Role of Formyl Peptide Receptors in Host Defense against Escherichia coli. . J Immunol. 2020,204(9):2464-2473.
  8. Lin S#, Wang X#, Pan Y#, Tian R, Lin B, Jiang GS, Chen K, He YQ, Zhang L, Zhai W, Jin P, Yang L, Li G, Wu Y, Hu J, Gong W, Chang Z, Sheng JQ, Lu Y, Wang JM, Huang J*. Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human Gastric Carcinogenesis by Interacting with Metallothionein 2A. Clin Cancer Res. 2019,25-3:1050-1062.
  9. Lin S#, Zhang Y, Hu Y, Yang B, Cui J, Huang J, Wang JM, Xing R*, Lu Y*. Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-κB-mediated expression of CEACAM1-3S in human gastric cancer. Gastric Cancer.2019,22(5):941-954.
  10. Yoshimura T#, McLean MH, Dzutsev AK, Yao X, Chen K, Huang J, Gong W, Zhou J, Xiang Y, H Badger J, O'hUigin C, Thovarai V, Tessarollo L, Durum SK, Trinchieri G, Bian XW, Wang JM*. The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance. J Immunol. 2018 Mar. 15;200(6):2174-2185.
  11. Wang XF#,Chen K, Yu Y,Xiang Y, Kim JH,Gong W,Huang J,Shi S, LiQ,Zhou M,Sayers T, Tewary P, Gao B, and Wang JM. Metformin sensitizes lung cancer cells to treatment by the tyrosine kinase inhibitor erlotinib. Oncotarget, 2017, Vol. 8, (No. 65), pp: 109068-109078.
  12. Lin B#, Zhou X#, Lin S, Wang X, Zhang M, Cao B, Dong Y, Yang S, Wang JM, Guo M*, Huang J*. Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma. J Mol Med (Berl). 2017; 95 (11): 1237–1249
  13. Jiao YY#, Fu YH, Yan YF, Hua Y, Ma Y, Zhang XJ, Song JD, Peng XL, Huang J, Hong,T, He JS*. A single intranasal administration of virus-like particle vaccine induces an efficient protection for mice against human respiratory syncytial virus. Antiviral Res. 2017 Aug; 144:57-69.
  14. Lin S#, Lin B, Wang X, Pan Y, Xu Q, He JS, Gong W, Xing R, He Y, Guo L, Lu Y, Wang JM, Huang J*. Silencing of ATP4B of ATPase H(+)/K(+) Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells. Oncol Res. 2017 Mar 13;25(3):317-329.
  15. Pan Y#, Lin S#, Xing R#, Zhu M, Lin B, Cui J, Li W, Gao J, Shen L, Zhao Y, Guo M, Wang JM, Huang J* Lu Y*: Epigenetic upregulation of metallothionein 2a by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel through attenuating nf-kappab activation. Antioxid Redox Signal 2016; 24 (15): 839-854.
  16. Xiang Y#, Yao X, Chen K, Wang X, Zhou J, Gong W, Yoshimura T, Huang J, Wang R, Wu Y, Shi G, Bian X, Wang J*. The G-protein coupled chemoattractant receptor FPR2 promotes malignant phenotype of human colon cancer cells. Am J Cancer Res. 2016; 6 (11):2599-2610.
  17. Xing R#, Li L, Chen L, Gao Z, Wang H, Li W, Cui J, Tian G, Liang Q, Yu J, Sung JJ, Luo G, Gao H, Xu X, Yang H, Wang J, Zhang X, Wang JM, Huang J, Yu Y, Wang J, Lu Y*. Copy number variations of HLA-I and activation of NKp30 pathway determine the sensitivity of gastric cancer cells to the cytotoxicity of natural killer cells. Oncogene. 2016 May 19;35(20):2584-91.
  18. Guo L#, Bai H, Zou D, Hong T, Liu J, Huang J, He P, Zhou Q, He J*. The role ofmicroRNA-133b and its target gene FSCN1 in gastric cancer. J Exp Clin Cancer Res. 2014 Nov 30;33(1):99. 
  19. Chen K#, Xiang Y, Huang J, Gong W, Yoshimura T, Jiang Q, Tessarollo L, Le Y, Wang JM*. The formylpeptide receptor 2 (Fpr2) and its endogenous ligand cathelin-related antimicrobial peptide (CRAMP) promote dendritic cell maturation. J Biol Chem. 2014 Jun 20; 289 (25): 17553-63.
  20. Pan Y#, Huang J#, Xing R, Yin X, Cui J, Li W, Yu J, Lu Y*. Metallothionein 2A inhibits NF-κB pathway activation and predicts clinical outcome segregated with TNM stage in gastric cancer patients following radical resection. J Transl Med. 2013 Jul 19;11:173.
  21. Kibe R#, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y*. IL-7Rapha deficiency in p53(null) mice exacerbates thymocyte telomere erosion and lymphomagenesis. Cell Death Differ. 2012; 19: 1139-51.
  22. Hamano, R.#, Huang, J., Toshimura, T., Howard, O.M. Z., Oppenheim, J.J., Chen, X*. TNF induces co-stimulatory TNF receptor superfamily member TNFR2, 4-1BB andOX40 on CD4+FoxP3+ regulatory T cells.  Eur. J. Immunol.  2011; 41: 2010-20.
  23. Tao Y#, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K*. Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences.  Proc Natl Acad Sci U S A. 2011; 108: 5626-31.
  24. Huang, J#., Chen, K., Huang, J., Gong, W., Dunlop, N.M., Howard, O.M., Bian, X., Gao, Y., Wang, J.M*. Regulation of the leukocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation. Carcinogenesis. 2009; 30: 348-55.
  25. Zhu, G.#, Augustine, M.M., Azuma, T., Luo, L., Yao, S., Anand, S., Rietz, A.C., Huang, J., Xu, H., Flies, A.S., Flies, S.J., Tamada, K., Colonna, M., van Deursen, J.M., Chen, L*. B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood. 2009; 113:1759-67.
  26. Jiang, Q#., Huang, J., Li, W.Q., Muegge, M., and Durum, S.K*. Role of the Intracellular Domain of IL-7 Receptor in T Cell Development. J. Immunol. 2007; 178: 228-234.
  27. Wang, L.H.#, Yang, X.Y., Zhang, X., An, P., Kim, H., Huang, J., Clarke, R., Osborne, C.K., Inman, J.K., Appella, E., and Farrar, L.W*. Disruption of estrogen receptor zinc finger domains and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer.  Cancer Cell. 2006; 10: 487-499.
  28. Huang, J.#, Fan, T., Yan, Q., Zhu, H., Fox, S., Issaq, H.J., Best, L., Gangi, L., Munroe, D. and Muegge, K*.  Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Res. 2004; 32: 5019-5018.
  29. Wang, L.H#., Yang, X.Y., Zhang, X., Huang, J., Mihalic, K., Zhu, H., Xiao, W., Muegge, K., Farrar, L.W*. Transcriptional inactivation of STAT3 by PPAR gamma suppresses IL-6-responsive multiple myeloma cells. Immunity. 2004; 20: 205-18.
  30. Yan, Q.#, Huang, J.#, Fan, T., Zhu, H., Muegge, K*. Lsh, a modulator of CpG methylation, is crucial for normal histone methylation. EMBO J. 2003; 19: 5154-5162.           
  31. Fan, T#. Yan, Q., Huang, J., Austin, S., Cho, E., Ferris, D., Muegge, K*. Lsh deficient murine embryonic fibroblasts show reduced proliferation with signs of abnormal mitosis.  Cancer Research. 2003; 63: 4677-4683.
  32. Khaled, A#. R, Li, W. Q., Huang, J., Fry, T. J, Khaled, A. S., Mackall, C. L., Muegge, K., Young, H. A., Durum, S. K*.  Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.  Immunity. 2002; 17: 561-573.
  33. Huang, J.#, Durum, S. K., and Muegge, K*. Cutting edge: Histone acetylation and recombination at the TCR gamma locus follows IL-7 induction. J. Immunol. 2001; 167: 6073-6077.
  34. Han W#, Lou Y, Tang J, Zhang Y, Chen Y, Li Y, Gu W, Huang J, Gui L, Tang Y, Li F, Song Q, Di C, Wang L, Shi Q, Sun R, Xia D, Rui M, Tang J, Ma D*. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. Biochem J. 2001 Jul 1;357(Pt 1):127-35.
  35. Huang, J#. & Muegge, K*. Control of chromatin accessibility for V(D)J recombination by interleukin7. J. Leukoc. Biol.  2001; 69:907-11.