CN EN

TIAN Tian

Professional title:Associate Professor

Office No.:010-51684351-803

Email:ttian@bjtu.edu.cn

Education

1999/09 –2003/07 China Agriculture University- biology- bachelor’s degree

2003/09 –2009/07 Tsinghua University- developmental biology- PhD. 

Professional Experience

During my doctoral study in the developmental biology of Tsinghua University, we used Tol2 transposon gene trap to screen mutanted gene of zebrafish in early embryo development (National 973 Project). I am specialized in the construction of zebrafish genetic mutants, screening of transgenic fish, functional gene and signal pathway analysis, etc., and published 4 SCI papers as the first author. As a postdoctoral fellow in cell Engineering Center of Air Force Military Medical University, I mainly established the standard bank for liver cancer sample bank, analyzed the transcriptome sequencing results, finished the functional research of differentially expressed genes and correlation analysis of clinical case data, etc., and published three SCI papers. During the government-sponsored visiting at Dana-Farber Cancer Institute of Harvard Medical School, I used CRISPR/Cas9 technology to mutate nf1, CasZ1 and other potential tumor suppressor genes in zebrafish, and established multiple mutant families of zebrafish, so as to simulate the occurrence and development of neuroblastoma in zebrafish models. Since I worked in Beijing Jiaotong University, I mainly engaged in the construction of zebrafish and mouse tumor models, functional genes and tumor microenvironment research, and has undertaken 6 scientific research projects of National Natural Science Foundation of China.

Research Field

Build up animal model in hepatocellular carcinoma and colorectal carcinoma

Functional analysis of key genes in carcinogenesis and microenvironment

Projects

  1. National Natural Science Foundation (Youth). 31301022. Functional analysis of two isoforms of ATAD2 gene in hepatocellular carcinoma and generation of corresponding inducible transgenic zebrafish model for HCC. 2014 /01-2016/12.
  2. Fundamental Research Fund for the Central Universities. Functional analysis of GTSE1 gene in colorectal carcinoma. 2015-2017.
  3. Fundamental Research Fund for the Central Universities. Multiple DEG screening and gene functional analysis in several cancer types. 2011-2013.
  4. Talent foundation in Beijing Jiaotong University. Research on zebrafish model in hepatocellular carcinoma and functional analysis. 2013.
  5. China postdoc foundation. Functional analysis of CD147 in zebrafish early embryo development.2009-2011.

Teaching Courses

Undergraduate students: general biology; cancer biology; the pathogenesis of serious disease

Graduate students: molecular biology

Paper

  1. Wang H, Tian T*, Zhang J*. Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis. Int. J. Mol. Sci. 2021, 22(16):8470. doi: 10.3390/ijms22168470 (co-corresponding author)
  2. Tian T, Xiaoyi L, Jinhua Z. mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy. Int. J. Mol. Sci. 2019, 20(3), 755;
  3. Tian T, Wang Z, Zhang J*. Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies. Oxidative Medicine and Cellular Longevity., DOI: 10.1155/2017/4535194.2017
  4. Tian T, Wang Y, Li J , Zhou F, Cao J, Wang Z, He X*, Su H*. Clinical significance of GTSE1 expression in colorectal carcinoma. Int J Clin Exp Pathol., 9(2): 1810-1818. 2016
  5. Tian,T., Zhang,E., Fei,F., Li,X., Guo,X., Liu,B., Li,J., Chen,Z*., and Xing,J*. Up-regulation of GTSE1 Lacks a Relationship with Clinical Data in Lung Cancer. Asian Pac.J.Cancer Prev., 12, 2039-2043. 2011
  6. Zhang G#, Tian T#, Liu Y, Wang H, Chen Q*.A laccase with anti-proliferative activity against tumor cells from a white root fungus Abortiporus biennis. Process Biochemistry ., 46, 2336-2340.2011
  7. Tian,T., Zhao,L., Zhao,X., Zhang,M., and Meng,A*. A zebrafish gene trap line expresses GFP recapturing expression pattern of foxj1b. J.Genet.Genomics, 36, 581-589. 2009
  8. Tian,T., Zhao,L., Zhang,M., Zhao,X., and Meng,A*. Both foxj1a and foxj1b are implicated in left-right asymmetric development in zebrafish embryos. Biochem.Biophys.Res.Commun., 380, 537-542. 2009
  9. Zhao,L. #, Zhao,X#., Tian,T#., Lu,Q., Skrbo-Larssen,N., Wu,D., Kuang,Z., Zheng,X., Han,Y., Yang,S., Zhang,C., and Meng,A*. Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovasc.Res., 80, 200-208. 2008
  10. Tian,T. and Meng,A *.Nodal signals pattern vertebrate embryos. Cell Mol.Life Sci., 63, 672-685. 2006