CN EN

HE Jinsheng

Professional title:Professor

Office No.:010-51684080

Email:jshhe@bjtu.edu.cn

Education

1981.09-1986.06 BS., Anhui Medical University, China

1990.09-1994.06 MS., Anhui Medical University, China

1998.09-2001.07 MD., Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, China

2004.10-2005.10 Visiting scholar, University of Toronto, Canada

Research Field

  1. Development of novel vaccine against human respiratory syncytial virus (RSV) infection: exploring the feasibility to improve the immunogenicity of the live RSV attenuated vaccines and adenovirus-vectored RSV vaccines; developing bivalent vaccine against viruses via respiratory tract transmission such as RSV and SARS-Cov-2.  
  2. Development of novel oncolytic virus: exploring the strategy and the underlying mechanism to enhance the specificity and effectiveness of oncolytic adenovirus.
  3. Development of the early and rapid diagnosis for AD: selecting monoclonal antibodies specific for Ab42 and Ab40 peptides and p-Tau, as well as establishing ELISA method to assay their serum concentration of these three pepties and proteins, which are the important bio-markers for the progression of AD.

Projects

  1. The National Natural Fund (32070922),Study on Live Attenuated Human Respiratory Syncytial Virus Vaccine with Chimeric SARS-CoV-2 Spike Protein, 2021-2024, Role: PI
  2. The National Natural Fund (81771777), Comparison of immunogenicity and protective effect of human respiratory syncytial virus replication-deficient vaccine with live-attenuated vaccine, 2018-2021, Role: PI
  3. National Major Scientific and Technological Special Project for "AIDS and Viral Hepatitis and Other Major Infectious Diseases Prevention and Control" (2013ZX10004-601), “High throughput screening platform for the biomarkers of pathogens for diagnosis and treatment by chemical genomics”. 2013-2015. Role: PI
  4. National Major Scientific and Technological Special Project for “Significant New Drugs Development” (2013ZX09103-003-011), “The development of the attenuated vaccine of respiratory syncytial virus”. 2013-2015. Role: PI
  5. The National Natural Fund (30972604), The investigation on enhancing the protective role of recombinant adenovirus-based Respiratory syncytial virus vaccine. 2010-2012,Role: PI
  6. The National Natural Fund (30671965), Human respiratory syncytial virus vaccine based on help-dependent adenovirus vector. 2007-2009. Role: PI
  7. The National Natural Fund (30371320), Protection immunity against RSV infection induced by DNA and replication-defective adenoviral recombinant encoding the attachment(G) and fusion(F) protein. 2004.1-2004.12. Role: PI
  8. The National Natural Fund (30471519), Oral DNA vaccination against respiratory syncytial virus infection among infant. 2005-2007. Role: PI
  9. National High Technology Research and Development Program of China (863 Program) (2006AA02A247), “Preparation, characterization and modification of amyloid-beta 42 oligomer-specific monoclonal antibody”. 2006-2010. Role: PI

Teaching Courses

Essential Immunology, Principles of Virology, Life Science: An Evolving Science 

Paper

  1. Jie‑Mei Yu, Yuan‑Hui Fu, Xiang‑Lei Peng, Yan‑Peng Zheng & Jin‑Sheng He. Genetic diversity and molecular evolution of human respiratory syncytial virus A and B, Scientific Reports (2021) 11:12941, https://doi.org/10.1038/s41598-021-92435-1
  2. Lingwan Xu, Shijun Tian, Xianglei Peng, Ying Hua, Wenxuan Yang, Longwei Chen, Shilei Liu, Wenzheng Wu, Jiang Zhao, Jinsheng He, Liqing Wu, Jingfa Yang, Yanpeng Zheng. Clusterin inhibits Aβ42 aggregation through a "strawberry model" as detected by FRET-FCS Journal of Neurochemistry, 2021, DOI: 10.1111/jnc.15344
  3. Li-Nan Wang, Xiang-Lei Peng, Min Xu, Yuan-Bo Zheng, Yue-Ying Jiao, Jie-Mei Yu, Yuan-Hui Fu, Yan-Peng Zheng, Wu-Yang Zhu, Zhong-Jun Dong, Jin-Sheng He, Evaluation of the Safety and Immune Efficacy of Recombinant Human Respiratory Syncytial Virus Strain Long Live Attenuated Vaccine Candidates. Virologica Sinica, 2021, DOI: 10.1007/s12250-021-00345-3
  4. Minghua Wang, Guoning Zhang, Jianyuan Zhao, Ningning Cheng, Yujia Wang, Yuanhui Fu, Yanpeng Zheng, Juxian Wang, Mei Zhu, Shan Cen, Jinsheng He, Yucheng Wang. Synthesis and antiviral activity of a series of novel quinolone derivatives as anti-RSV or anti-IAV agents. European Journal of Medicinal Chemistry, 214 (2021) 113208, DOI: 10.1016/j.ejmech.2021.113208
  5. Jie-Mei Yu, Li-Shu Zhang, Yuan-Hui Fu, Feng-Min Ji, Han-Li Xu, Jia-Qiang Huang, Xiang-Lei Peng, Yan-Peng Zheng, Ying Zhang and Jin-Sheng He. Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2. Evolutionary Bioinformatics, 2020, Volume 16: 1–6, DOI: 10.1177/1176934320954870
  6. Guo-Ning Zhang, Qiang Li, Jianyuan Zhao, Xuandi Zhang, Zhuxin Xu, Yujia Wang, Yuanhui Fu, Qi Shan, Yanpeng Zheng, Juxian Wang, Mei Zhu, Ziqiang Li, Shan Cen, Jinsheng He, Yucheng Wang. Design and synthesis of 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides as novel dual inhibitors of respiratory syncytial virus and influenza virus A. European Journal of Medicinal Chemistry, 186 (2020) 111861
  7. Shuo Xiao, Lin-Lin Song, Jiang-Tao Li, He Wang, Na Yu, Zi-Qi Wang, Ying Zhang, Jin-Sheng He, and Tao Hung. Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Ab42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice. Journal of Alzheimer’s Disease, 73 (2020) 657–670, DOI 10.3233/JAD-190874
  8. Yuan-Hui FU; Zhu-Xin XU; Nan Jiang; Yan-Peng Zheng; Marie-Anne Rameix-Welti; Yue-Ying Jiao; Xiang-Lei Peng; Ye Wang; Jean-Francois Eleouet; Shan Cen; Jinsheng He. High-throughput screening of active compounds against human respiratory syncytial virus. Virology, 535 (2019) 171–178
  9. Zheng, Yanpeng; Xu, Lingwan; Yang, Jingfa; Peng, Xianglei; Wang, He; Yu, Na; Hua, Ying; Zhao, Jiang; He, Jinsheng; Hong, Tao. The effects of fluorescent labels on Abeta42 aggregation detected by fluorescence correlation spectroscopy. Biopolymers, e23237, 2018-Oct-11, DOI: 10.1002/bip.23237
  10. Zhang, Xiujuan; Ding, Xiaohui; Zhu, Yuanmei; Chong, Huihui; Cui, Sheng; He, Jinsheng; Wang, Xinquan; He, Yuxian. Structural and functional characterization of HIV-1 cell fusion inhibitor T20. AIDS (London, England) , 2019-Jan-01, DOI: 10.1097/QAD.0000000000001979
  11. Xiujuan Zhang, Yuanmei Zhu, Hao Wu, Senyan Zhang, Pengfei Wang, Huihui Chong, Jinsheng He, Xinquan Wang, Yuxian He. Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket. Frontiers in Cellular and Infection Microbiology 2018, 8:51. doi: 10.3389/fcimb.2018.00051
  12. Yao Ma, Yue-Ying Jiao, Yun-Zhou Yu, Nan Jiang, Ying Hua, Xiu-Juan Zhang, Yuan-Hui Fu, Xiang-Lei Peng, Yan-Peng Zheng, Larry J. Anderson, and Jin-Sheng He. A Built-In CpG Adjuvant in RSV F Protein DNA Vaccine Drives a Th1 Polarized and Enhanced Protective Immune Response. Viruses 2018, 10, 38; doi:10.3390/v10010038.
  13. Min Xu, Yue-Ying Jiao, Yuan-Hui Fu, Nan Jiang, Yuan-Bo Zheng, Yi-Fei Yan, Mei Zhang, Yan-Peng Zheng, Wu-Yang Zhu, Xiang-Lei Peng, Jin-Sheng He. Construction and characterization of a recombinant human respiratory syncytial virus encoding enhanced green fluorescence protein for antiviral drug screening assay. BioMed Research International, Volume 2018, Article ID 8431243, 8 pages,https://doi.org/10.1155/2018/8431243
  14. Yue-Ying Jiao, Yuan-Hui Fu, Yi-Fei Yan, Ying Hua, Yao Ma, Xiu-Juan Zhang, Jing-Dong Song, Xiang-Lei Peng, Jiaqiang Huang, Tao Hong, Jin-Sheng He. A single intranasal administration of virus-like particle vaccine induces an efficient protection for mice against human respiratory syncytial virus. Antiviral Research, 2017,144:57-69.
  15. Ying Hua, Yue-Ying Jiao, Yao Ma, Xiang-Lei Peng, Yuan-Hui Fu, Xiu-Juan Zhang, Yuan-Bo Zheng, Yan-Peng Zheng, Tao Hong, Jin-Sheng He. Enhanced humoral and CD8 + T cell immunity in mice vaccinated by DNA vaccine against human respiratory syncytial virus through targeting the encoded F protein to dendritic cells. International Immunopharmacology, 2017, dx.doi.org/10.1016/j.intimp.2017,46:62-69.
  16. Yuan-Hui Fu Ya-Ru Liu Yan-Peng Zheng Nan Jiang Yue-Ying-Jiao Yao Ma Wei Li Xiang-lei Peng Jinsheng He. An RNA polymerase I-driven human respiratory syncytial virus minigenome as a tool for quantifying virus titers and screening antiviral drug. Chinese Chemical Letters, 2017, 28: 131-135  
  17. Ying Hua Yue-Ying Jiao Yao Ma Xiang-Lei Peng Yuan-Hui Fu Yan-Peng Zheng Tao Hong Jin-Sheng He. DNA Vaccine Encoding Central Conserved Region of G Protein Induces Th1 Predominant Immune Response and Protection from RSV Infection in Mice. Immunology Letters, 2016,179:95-101  
  18. Zheng, YP; Tian, SJ; Peng, XL; Yang, JF; Fu, YH; Jiao, YY; Zhao, J; He, JS; Hong. Kinesin-1 inhibits the aggregation of amyloid-beta peptide as detected by fluorescence cross-correlation spectroscopy. FEBS LETTERS, 2016, 590(7): 1028-1037
  19. Lihua Guo, Hua Bai, Dongling Zou, Tao Hong, Jie Liu, Jiaqiang Huang, Pengfei He, Qi Zhou, and Jinsheng He. The role of microRNA-133b and its target gene FSCN1 in gastric cancer. Journal of Experimental & Clinical Cancer Research, 2014, 33:99, doi:10.1186/s13046-014-0099-0
  20. Xianglei Peng, Lei Hou, Shaohua Xu, Ying Hua, Shujie Zhou, Ying Zhang, Yanpeng Zheng, Yuanhui Fu, Qing Xu, Lishu Zhang, Jun Wang, Xiaoting Guan, Jinsheng He. Novel APP K724M mutation causes Chinese EOFAD and increases amyloid-β42 to 40 ratio. Neurobiology of aging, 2014, 35(11):2657e1-2657e6, DOI:10.1016/j.neurobiolaging.2014.06.005
  21. Yuan-Hui Fu Yue-Ying Jiao Jinsheng He Gui-Yun Jiang Wei Zhang Yao Ma Ying Zhang Chang-Xin Shi Xiang-Lei Peng Tao Hong Yi-Fei Yan. Sublingual administration of a helper-dependent adenoviral vector expressing the codon-optimized soluble fusion glycoprotein of human respiratory syncytial virus elicits protective immunity in mice. Antiviral Research 105 (2014), 72-79, DOI: 10.1016/j.antiviral.2014.02.003
  22. Li-Hua Guo, Hui Li, Fang Wang, Jia Yu, and Jin-Sheng He. The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer. Int. J. Mol. Sci. 2013, 14, 14171-14184; doi:10.3390/ijms140714171
  23. Yuan-hui Fu, Jin-sheng He, Wei Qiao, Yue-ying Jiao, Ying Hua, Ying Zhang, Xiang-Lei Peng, and Tao Hong. Intranasal immunization with a helper-dependent adenoviral vector expressing the codon-optimized fusion glycoprotein of human respiratory syncytial virus elicits protective immunity in BALB/c mice. Virol J, 2013, 10:183. DOI: 10.1186/1743-422X-10-183
  24. Zheng YP, Tang Y, Fu YH, He JS, Wang XB, Hong T. Purification of human respiratory syncytial virus fusion glycoprotein. Protein Expr. Purif, 2012, 81(1): 115-118
  25. Lv RJ, He JS, Fu YH, Zhang YQ, Shao XQ, Wu LW, Lu Q, Jin LR, Liu H. ASIC1a polymorphism is associated with temporal lobe epilepsy. Epilepsy Res, 2011, 96(1-2): 74-80
  26. Lv RJ, He JS, Fu YH, Shao XQ, Wu LW, Lu Q, Jin LR, Liu H. A polymorphism in CALHM1 is associated with temporal lobe epilepsy. Epilepsy Behav, 2011, 20(6): 681-685
  27. Zhang Y, He JS, Guo SH, et al. Morphology and structural dynamics of amyloid beta 42 assembly in vitro. Neural Regeneration Research, 2011, 6(5): 335-339
  28. Ying Zhang, Jin-Sheng HE, Xin WANG, Jun Wang, Fu-Xiang BAO, Si-Yuan Pang, Fan Yin, Tao Hong. Administration of Amyloid-b42 Oligomer-Specific Monoclonal Antibody Improved Memory Performance in SAMP8 Mice. J Alzheimers Dis, 2011, 23 (3): 551-561
  29. Yuan-hui Fu, Rui-juan Lv, Li-ri Jin, Qiang Lu, Xiao-qiu Shao, Jin-sheng He, Li-wen Wu, Li-shu Zhang, Hong-gang Hu. Association of apolipoprotein E polymorphisms with temporal lobe epilepsy in a Chinese Han population. Epilepsy Res, 2010, 91(2-3): 253-259
  30. HE JinSheng, ZHANG Ying, HONG Tao. Progress in the development of therapeutic antibodies targeting prion proteins and β-amyloid peptides. Sci China Life Sci, 2010, 53(8): 959-963
  31. ZhENG YanPeng, HE JinSheng & HONG Tao. Biomarkers of Alzheimer’s disease in body fluids. Sci China Life Sci, 2010, 53(4): 490-496
  32. Yuan-hui Fu, Jin-sheng He, Xiao-bo Wang, Xian-Xian Zheng, Qiang Wu, Can Xie, Wei Wei, Qian Tang, Jing-Dong Song, Jian-Guo Qu, Tao Hong. A prime–boost vaccination strategy using attenuated Salmonella typhimurium and a replication-deficient recombinant adenovirus vector elicits protective immunity against human respiratory syncytial virus. Biochem Biophys Res Commun, 2010, 395(1): 87-92
  33. Yuanhui Fu, Jinsheng He, Xianxian Zheng, Xiao-bo Wang, Can Xie, Chang-xin Shi, Mei Zhang, Qian Tang, Wei Wei, Jian-guo Qu and Tao Hong. Intranasal vaccination with a helper-dependent adenovirus vector enhances transgene-specific immune responses in BALB/c mice. Biochem Biophys Res Commun, 2010, 391(1): 857-861
  34. Zhang Ying, Wang Xin, He Jin-sheng, Bao Fu-Xiang, Sun Wei-Min, Dai Xin-Xian, Wang Xiao-Bo, Li Yi-Qin, Zhen Xian-Xian, Hu Hong-Gang, Peng Xiang-Lei, Zheng Yan-Peng, Hou Ling-Ling, and Hong Tao. Preparation and Characterization of a Monoclonal Antibody with High Affinity for Soluble Ab Oligomers. Hybridoma, 2009, 28 (5): 349-354
  35. Yuanhui Fu, Jinsheng He, Xianxian Zheng, Qiang Wu, Mei Zhang, Xiaobo Wang, Yan Wang, Can Xie, Qian Tang, Wei Wei, Min Wang, Jingdong Song, Jianguo Qu, Ying Zhang, Xin Wang, Tao Hong. Intranasal Immunization with a Replication-Deficient Adenoviral Vector Expressing the Fusion Glycoprotein of Respiratory Syncytial Virus Elicits Protective Immunity in BALB/c Mice. Biochem Biophys Res Commun, 2009, 381(4):528-532
  36. Can Xie, Jin-sheng He, Mei Zhang, Shao-Li Xue, Qiang Wu, Xiang-Dong Ding, Wei Song, Yuan Yuan, Dong-Liang Li,  Xian-Xian Zheng, Yan-Yan Lu and Zhi Shang. Oral RSV DNA Vaccine expressing RSV F Protein Delivered by Attenuated Salmonella Typhimurium. Human Gene Therapy, 2007, 18(8):746-752