刘飞
博士、副教授
基本信息
| 办公电话： | 电子邮件： liufei@bjtu.edu.cn |
| 通讯地址： | 邮编： |
教育背景
2003.09- 2008.07 浙江大学 工学学士2008.09- 2013.07 清华大学 工学博士
工作经历
2013.07- 2015.06 清华大学 医学院 博士后2015.06- 今 北京交通大学 计算机与信息技术学院 副教授
研究领域：
医学成像与图像处理
分子影像技术
荧光分子成像方法及应用
多模态生物医学成像技术
研究方向
招生专业
科研项目
主持
[1] 2019.01- 2022.12 国家自然科学基金面上项目“面向肿瘤转移早期检测的代谢参数荧光分子深度网络成像方法研究”
[2] 2015.01- 2015.12 国家自然科学基金青年科学基金项目“荧光分子动态参数反演成像方法研究”
[3] 2014.05- 2015.07 中国博士后科学基金面上资助（一等）项目“用于动态荧光分子断层成像的少角度断层重建方法研究”
参与
[1] 2008.09- 2013.12国家自然科学基金项目“基于空间编码并行激发的荧光分子断层成像方法的研究”
[2] 2011.01- 2015.12 国家973计划项目 “多模态分子影像成像理论和重建算法”
[3] 2011.01- 今 国家重大科学仪器设备开发专项 “FMT系统核心器件与关键技术研发”
[4] 2013.01- 今 国家自然科学基金国家重大科研仪器设备研制专项项目 “多模态成像模型和重建算法研究”
[5] 2013.01- 今 国家自然科学基金面上项目 “动态荧光分子断层成像的建模与重建方法研究”
教学工作
本人在信号处理、图像处理、分子影像成像方法及应用等方面有近10年的研究经历，积累了丰富的研究经验，可以为研究生提供良好的研究实验平台；与清华大学有密切的联系和项目合作，可以为研究生提供进入清华大学学习与交流的机会。欢迎生物医学工程、信号与信息处理、电子工程和计算机等专业的学生加入我们的团队。论文/期刊
共发表学术论文68篇（SCI收录57篇，EI收录3篇）。[1] G. Zhang#, F. Liu#, J. Liu, J. Luo, Y. Xie, J. Bai, and L. Xing, “Cone Beam X-ray Luminescence Computed Tomography Based on Bayesian Method”, IEEE Trans Med Imaging. vol. 36, no. 1, pp.225-235, Jan. 2017(#共同第一作者，SCI收录)
[2] W. Zhao#, F. Liu#, Y. Chen, J. Bai, and W. Gao, “Synthesis of well-defined protein–polymer conjugates for biomedicine”, Polymer, vol. 66, pp.A1-A10, 2015. (#共同第一作者)
[3] Y. Li#, W. Liu#,F. Liu#, Y. Zeng, S. Zuo, S. Feng, C. Qi, B. Wang, X. Yan, A. Khademhosseini, J. Bai, and Y. Du, “Primed 3D Injectable Micro-Niches Enabling Low-dosage Cell Therapy for Critical Limb Ischemia”,Proc Natl Acad Sci USA, vol. 111,no37, pp.13511-13516, Sep. 2014. (#共同第一作者，SCI收录)
[4] F. Liu, X. Cao, S. Liu, B. Zhang, W. He, J. Song, Z. Dai, B. Zhang, J. Luo, Y. Li, B. Shan, and J. Bai, “Monitoring of tumor response to cisplatin with simultaneous fluorescence and positron emission tomography: a feasibility study,”J Biophotonics,vol. 7,no11-12, pp.889-896,Nov. 2014.(Front Cover Picture，SCI收录)
[5] F. Liu, Y. Zhang, S. Liu, B. Zhang, Q. Liu, Y. Yang, B. Zhang, J. Luo, B. Shan and J. Bai, “Monitoring of tumor response to Au nanorod-indocyanine green conjugates mediated therapy with fluorescence imaging and positron emission tomography,” IEEE Trans Multimedia, vol. 15,no5, pp.1025-1030,Aug. 2013. (SCI收录)
[6] F. Liu, M. Li, B. Zhang, J. Luo, and J. Bai, “Weighted depth compensation algorithm for fluorescence molecular tomography reconstruction,” Appl Opt.,vol. 51,no 36, pp.8883-8892, Dec. 2012. (SCI收录)
[7] F. Liu, X. Cao, W. He, J. Song, Z. Dai, B. Zhang, J. Luo, Y. Li, and J. Bai, “Monitoring of tumor response to cisplatin by subsurface fluorescence molecular tomography,”J Biomed Opt., vol. 17, no. 4, pp. 040504, Apr. 2012. (SCI收录)
[8] F. Liu, X. Liu, D. Wang, B. Zhang, and J. Bai, “A parallel excitation based fluorescence molecular tomography system for whole-body simultaneous imaging of small animals,” Ann Biomed Eng., vol. 38, no. 11, pp. 3440-3448, Nov. 2010.(SCI收录)
[9] F. Liu, X. Liu, B. Zhang, and J. Bai, “Extraction of target fluorescence signal from in vivo background signal with image subtraction algorithm,”Int J Autom Comput., vol. 9, no.3, pp. 232-236, Jun. 2012. (EI 收录)
[10] J. Bai, F. Liu, and X. Liu, “Progress on multi-modality molecular imaging,”Curr Med Imaging Rev.,vol. 8no4, pp. 295-301, Nov. 2012. (导师一作，SCI收录)
[11] 刘飞, 王鑫, 白净, “荧光分子成像技术在肿瘤检测中的应用,” 生物医学工程学杂志, 卷27，期5，页1152-1157，2010年10月.
[12] X. Zhang, F. Liu∗，S. Zuo, J. Bai, and J. Luo∗, “Image reconstruction for synchronous data acquisition in fluorescence molecular tomography,” Journal of X-Ray Science and Technology, vol. 23, no. 2015, pp. 463-472, Apr. 2015. (*共同通讯作者)
[13] M. Sun, F, Liu, Y, Zhu, W. Wang, J. Hu, J. Liu, Z. Dai, K. Wang, Y. Wei, J. Bai, and W. Gao*, “Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer,” Nanoscale, vol. 8, no. 8, pp.4452-4457, Feb. 2016. (SCI收录)
[14] J. Zhang, J. Shi, H. Guang, S. Zuo, F. Liu, J. Bai and J. Luo，“Iterative Correction Scheme based on Discrete Cosine Transform and L1 Regularization for Fluorescence Molecular Tomography with Background Fluorescence,” IEEE Transactions on Biomedical Engineering, online. (SCI收录)
[15] C. Shi , Y. Cheng∗ , F. Liu , Y. Wang, J. Bai, and Shinichi Tamura, “A hierarchical local region-based sparse shape composition for liver segmentation in CT scans,” Pattern Recognition, vol. 50, pp. 88-106, Feb. 2016. (SCI收录)
[16] Y. Lv, J. Zhang, F. Liu, J. Shi, H. Guang, J. Bai, and J. Luo∗, “Spectral selective fluorescence molecular imaging with volume holographic imaging system,” Journal of the Innovative Optical Health Sciences, vol. 9, no.5, pp. 1650010, 2016. (SCI收录)
[17] X. Zhang, F. Liu，S. Zuo, J. Zhang, J. Bai, and J. Luo∗, “Fast reconstruction of fluorophore concentration variation based on the derivation of the diffusion equation,” Journal of the Optical Society of America A, vol. 32, no.11, pp. 1993-2001, Nov. 2015. (SCI收录)
[18] J. Zhang, J. Shi, S. Zuo, F. Liu, J. Bai, and J. Luo, “Fast reconstruction in fluorescence molecular tomography using data compression of intra- and inter-projections,” Chinese Optics Letters, vol. 13, no. 7, pp.071002 , Jul. 2015. (SCI收录)
[19] J. Shi, F. Liu, J. Zhang, J. Luo, J. Bai,“Fluorescence molecular tomography reconstruction via discrete cosine transform-based regularization,”J Biomed Opt.,vol. 20no5, pp. 55004, May. 2015. (SCI收录)
[20] G. Zhang, W. He, H. Pu, F. Liu, M. Chen,J. Bai,and J. Luo,“Acceleration of dynamic fluorescence molecular tomography with principal component analysis,” Biomed Opt Express, vol. 6, no.6, pp. 2036-2055, 2015. (SCI收录)
[21] G. Zhang, H. Pu, W. He, F. Liu, J. Luo, and J. Bai, “Full-direct method for imaging pharmacokinetic parameters in dynamic fluorescence molecular tomography,” Applied Physics Letters, vol.106, no.8, pp. 081110, 2015. (SCI收录).
[22] G. Zhang, H. Pu, W. He, F. Liu, J. Luo*, and J. Bai, “Bayesian Framework Based Direct Reconstruction of Fluorescence Parametric Images,” IEEE Trans Med Imaging, vol. 34, no.6, pp. 1378-1391, Jun 2015..(SCI收录)
[23] X. Zhang, F. Liu, S. Zuo, J. Shi, G. Zhang, J. Bai, and J. Luo, “Reconstruction of fluorophore concentration variation in dynamic fluorescence molecular tomography,” IEEE Trans Biomed Eng., vol. 62, no.1, pp. 138-144, Jan. 2015. (SCI收录)
[24] J. Shi, F. Liu, H. Pu, S. Zuo, J. Luo, and J. Bai, “An adaptive support driven reweighted L1-regularization algorithm for fluorescence molecular tomography,” Biomed Opt Express, vol. 5no.11, pp. 4039-4052, Oct. 2014. (SCI收录)
[25] J. Zhang,J. Shi,X. Cao,F. Liu,J. Bai,and J. Luo,“Fast reconstruction of fluorescence molecular tomography via a permissible region extraction strategy,” J Opt Soc Am A.,vol. 31no.8, pp. 1886-1894, Aug. 2014. (SCI收录)
[26] H. Pu, G. Zhang,W. He, F. Liu, H. Guang, Y. Zhang, J. Bai and J. Luo, “Resolving fluorophores by unmixing multispectral fluorescence tomography with independent component analysis,”Phys Med Biol., vol. 59no.17, pp. 5025-5042, Aug. 2014. (SCI收录)
[27] W. He, G. Zhang, H. Pu, F. Liu, X. Cao, J. Luo, and J. Bai, “Modified forward model for eliminating the time-varying impact in fluorescence molecular tomography,” J Biomed Opt., vol. 19, no. 5, pp. 056012, May, 2014 (SCI收录)
[28] Y. Zhang, B. Zhang, F. Liu, J. Luo, and J. Bai, “In vivo tomographic imaging with fluorescence and MRI using tumor-targeted dual-labeled nanoparticle,”Int J Nanomedicine, vol. 9, pp. 33-41, 2014. (SCI收录).
[29] J. Shi, F. Liu, G. Zhang, J. Luo, and J. Bai, “Enhanced spatial resolution in fluorescence molecular tomography using restarted L1-regularized nonlinear conjugate gradient algorithm,” J Biomed Opt.vol. 19no.4, pp. 046018, Apr. 2014. (SCI收录).
[30] G. Zhang, F. Liu, H.Pu, W. He, J. Luo, and J. Bai, “A direct method with structural priors for imaging pharmacokinetic parameters in dynamic fluorescence molecular tomography,”IEEE Trans Biomed Eng.,vol. 61no.3, pp.986-990, Mar. 2014. (SCI收录).
[31] B. Zhang, F. Gao, M. Wang,X. Cao, F. Liu, X. Wang, J. Luo, G. Wang, and J. Bai, “In vivo tomographic imaging of lung colonization of tumour in mouse with simultaneous fluorescence and X-ray CT,”J Biophotonics,vol.7 no. 1-2, pp.110-116,Jan. 2014. (SCI收录).
[32] W. He, H. Pu, G. Zhang, X. Cao, B. Zhang, F. Liu, J. Luo,and J. Bai, “Subsurface fluorescence molecular tomography with prior information,”Appl Opt., vol. 53no.3, pp.402-409, Jan. 2014. (SCI收录).
[33] X. Wang, B. Zhang, X. Cao, F. Liu, J.Luo, and J. Bai, “Acceleration of early-photon fluorescence molecular tomography with graphics processing units,”Comput Math Methods Med,vol. 2013,2013. (SCI收录)
[34] J. Shi,B. Zhang,F. Liu,J. Luo,and J. Bai, “Efficient L1 regularization-based reconstruction for fluorescent molecular tomography using restarted nonlinear conjugate gradient,”Opt Lett., vol. 38, no. 18, pp.3696-3699, Sep. 2013. (SCI收录)
[35] H. Pu, W. He,G. Zhang, B. Zhang, F. Liu,Y. Zhang, J. Luo, and J. Bai, “Separating structures of different fluorophore concentrations by principal component analysis on multispectral excitation-resolved fluorescence tomography images,”Biomed Opt Express, vol. 4no.10, pp. 1829-1845, Aug. 2013. (SCI收录)
[36] B. Zhang, S. Liu, X. Cao, F. Liu, X. Wang, J. Luo, B. Shan and J. Bai, “Fluorescence tomography reconstruction with simultaneous positron emission tomography priors,” IEEE Trans Multimedia, vol. 15,no5, pp.1031-1038,Aug. 2013. (SCI收录)
[37] G. Zhang, F. Liu, B. Zhang, Y. He, J. Luo, and J. Bai, “Imaging of pharmacokinetic rates of indocyanine green in mouse liver with a hybrid fluorescence molecular tomography/x-ray computed tomography system,”J Biomed Opt.vol. 18no.4, pp. 040505, Apr. 2013. (SCI收录).
[38] J. Shi,X. Cao,F. Liu,B. Zhang,J. Luo,and J. Bai, “Greedy reconstruction algorithm for fluorescence molecular tomography by means of truncated singular value decomposition conversion,” J Opt Soc Am A., vol. 30no.3, pp. 437-447, Mar. 2013. (SCI收录)
[39] X. Cao, B. Zhang, X. Wang, F. Liu, K. Liu, J. Luo, and J. Bai, “An adaptive Tikhonov regularization method for fluorescence molecular tomography,”Med Biol Eng Comput, vol.51 no. 8, pp. 849-858, Mar. 2013. (SCI收录)
[40] G. Zhang, X. Cao, B. Zhang, F. Liu, J. Luo and J. Bai, “MAP estimation with structural priors for fluorescence molecular tomography”, Phys Med Biol., vol. 58no.2, pp. 351-372, Jan 2013. (SCI收录)
[41] X. Cao, X. Wang, B. Zhang, F. Liu, J. Luo, and J. Bai, “Accelerated image reconstruction in fluorescence molecular tomography using dimension reduction,”Biomed Opt Express, vol.4, no. 1, pp.1-14, Jan. 2013. (SCI收录)
[42] X. Wang, X. Cao, B. Zhang, F. Liu, J. Luo and J. Bai, “A hybrid reconstruction algorithm for fluorescence tomography using Kirchhoff approximation and finite element method,”Med Biol Eng Comput, vol. 51, no. 1-2, pp.7-17, Feb. 2013. (SCI收录)
[43] X. Zhao, H. Liu, B. Zhang, F. Liu, J Luo, and J. Bai “Fast photon-boundary intersection computation for Monte Carlo simulation of photon migration,”Opt Eng., vol. 52, no. 1, pp. 019001, Jan. 2013. (SCI收录)
[44] B. Shi, B. Zhang, F. Liu, J. Luo, and J. Bai, “360° fourier transform profilometry in surface reconstruction for fluorescence molecular tomography,”IEEE Journal of Biomedical and Health Informatics,vol. 17, no.3, pp. 681-689, May 2013. (SCI收录)
[45] Y. He, X. Cao, F. Liu, J. Luo and J. Bai, “Influence of limited-projection on fluorescence molecular tomography,” J Innov Opt Health Sci., vol. 5, no.3, pp. 1250020, Jul. 2012. (SCI收录2)
[46] M. Li, F. Liu, B. Zhang, and J. Bai, “Diffuse optical tomography guided adaptive reconstruction in fluorescence molecular tomography,” J Electron Imaging, vol. 21, no.2, pp. 023014, Jun. 2012. (SCI收录)
[47] M. Li, X. Cao, F. Liu, B. Zhang, J. Luo, and J. Bai, “Reconstruction of fluorescence molecular tomography using a neighborhood regularization,”IEEE Trans Biomed Eng., vol. 59, no.7, pp. 1799-1803, Jul. 2012. (SCI收录)
[48] Y. Liu, B. Shen, F. Liu, B. Zhang, T. Chu, J. Bai, and S. Bao, “Synthesis, radiolabeling, biodistribution and fluorescent imaging of histidine-coupled hematoporphyrin,” Nucl Med Biol., vol. 39, no. 4, pp. 579-585, May 2012. (SCI收录)
[49] B. Zhang, S. Liu, F. Liu, X. Zhang, Y. Xu, J. Luo, B. Shan, and J. Bai, “Simultaneous fluorescence and positron emission tomography for in vivo imaging of small animals, ” J Biomed Opt., vol. 16, no. 12, pp. 120511, Dec. 2011. (SCI收录)
[50] X. Cao, B. Zhang, F. Liu, X. Wang, and J. Bai, “Reconstruction for limited-projection fluorescence molecular tomography based on projected restarted conjugate gradient normal residual,” Opt Lett., vol. 36, no. 23, pp. 4515-4517, Dec. 2011. (SCI收录)
[51] B. Zhang, X. Cao, F. Liu, X. Liu, X. Wang, and J. Bai, “Early-photon fluorescence tomography of a heterogeneous mouse model with the telegraph equation,” Appl Opt., vol. 50, no. 28, pp. 5397-5407, Oct. 2011. (SCI收录)
[52] X. Liu, F. Liu, Y. Zhang, and J. Bai, “Unmixing dynamic fluorescence diffuse optical tomography images with independent component analysis,”IEEE Trans Med Imaging, vol. 30, no. 9, pp. 1591-1604, Sep. 2011. (SCI收录)
[53] X. Liu, X. Guo, F. Liu, Y. Zhang, H. Zhang, G. Hu, and Jing Bai, “Imaging of indocyanine green perfusion in mouse liver with fluorescence diffuse optical tomography,” IEEE Trans Biomed Eng., vol. 58, no. 8, pp. 2139-2143, Aug. 2011. (SCI收录)
[54] X. Liu, F. Liu, and J. Bai, “A linear correction for principal component analysis of dynamic fluorescence diffuse optical tomography images”, IEEE Trans Biomed Eng., vol. 58, no. 6, pp. 1602-1611, Jun. 2011. (SCI收录)
[55] S. Liu, B. Zhang, X. Wang, L. Li, Y. Chen, X. Liu, F. Liu, B. Shan, and J. Bai, “A dual modality system for simultaneous fluorescence and positron emission tomography imaging of small animals,” IEEE Trans Nucl Sci. vol. 58, no. 1, pp. 51-57, Feb. 2011. (SCI收录)
[56] X. Wang, B. Zhang, X. Cao, F. Liu, S. Liu, B. Shan, and J. Bai, “In vivo validation of dual-modality system for simultaneous PET and optical tomographic imaging,” J Innov Opt Health Sci,vol. 4, no. 2, pp. 165-171, Feb. 2011. (EI收录)
[57] D. Wang, X. Liu, F. Liu, and J. Bai, “Full angle fluorescence diffuse optical tomography with spatially coded parallel excitation,” IEEE Trans Inf Technol Biomed., vol. 14, no. 6, pp. 1346–1354, Nov. 2010. (SCI收录)
[58] X. Guo, X. Liu, X. Wang, F. Tian, F. Liu, B. Zhang, G. Hu, and J. Bai, “A combined fluorescence and microcomputed tomography system for small animal imaging,” IEEE Trans Biomed Eng., vol. 57, no. 12, pp. 2876-2883, Dec. 2010. (SCI收录)
[59] X. Liu, F. Liu, D. Wang, and J. Bai, “In vivo whole-body imaging of optical agent dynamics using full angle fluorescence diffuse optical tomography,” Chin Opt Lett.,vol. 8, no. 12, pp. 1156-1159, Dec. 2010. (SCI收录)
[60] X. Liu, D. Wang, F. Liu, and J. Bai, “Principal component analysis of dynamic fluorescence diffuse optical tomography images,” Opt Express, vol. 18, no. 6, pp. 6300-6314, Mar. 2010. (SCI收录)
[61] X. Liu, Y. Zhang, F. Liu, X. Guo, X. Wang, and J. Bai, “Performance of hybrid system for fluorescence and micro-computed tomography in synchronous mode,”Proc. SPIE, vol.7845, pp. 78450G, Nov. 2010.(oral) (EI收录)
[62] 吕衍路，刘飞，白净, “体全息成像系统研究进展,”国际生物医学工程, 卷37，期3，页170-178，2014年6月.
[63] 周源，刘飞，阮秋琦，白净, “基于荧光分子断层成像的多模成像系统研究进展,”国际生物医学工程, 卷37，期1，页43-48，2014年2月.
[64] 濮黄生，张宾，刘飞，刘欣，白净，“荧光分子成像的探针技术及应用,”国际生物医学工程杂志，卷35，期4，页220-223，2012年8月.
[65] 刘睛，谢欣，张玥，刘飞，张宾，白净，“金纳米材料复合型光敏剂介导的近红外光照治疗对于4T1乳腺癌细胞生长抑制效果的实验研究,”国际生物医学工程杂志，卷35，期3，页129-132，136，2012年6月.
[66] 张光磊，刘飞，张宾，白净，“动态荧光分子成像技术研究进展,”国际生物医学工程杂志，卷35，期3，页181-184，2012年6月.
[67] 陈劲松, 曹旭, 何耘, 刘飞, 张宾, 白净, “基于CT轮廓信息的荧光分子断层重建软件的设计与实现,”国际生物医学工程杂志，卷35，期5，页257-261，2012年1月.
[68] 王鑫, 刘飞, 李明泽, 刘欣, 白净, “多模式成像技术概述以及研究进展,” 国际生物医学工程杂志, 卷33，期2，页99-105，2010年4月.
专著/译著
专利
[1] Bai J, Liu F, Wang D F, et al. Parallel excitation system capable of spatial encoding and method thereof: Canada, CA 2782964.[2] 白净, 刘飞,汪待发, 等. 一种可空间编码的并行激发系统及方法: 中国, ZL 2010 8 0000866.2.
[3] 白净, 汪待发, 刘欣, 刘飞. 一种荧光分子体成像系统及方法. PCT, PCT/CN2009/000717.
[4] 白净, 石璧尔, 张宾, 刘飞. 一种物体表面三维轮廓成像装置: 中国, ZL 2012 2 0645603.3.
[5] 白净, 曹旭, 张宾, 刘飞, 王鑫. 一种大数据量荧光分子断层成像重建方法: 中国, ZL 201210293156.4.
[6] 白净, 左思敏, 刘飞 何耘, 曹良才. 一种全息荧光分子成像系统及方法. PCT, PCT/CN2013/000726.
[7] 白净, 左思敏, 刘飞, 何耘, 曹良才. 一种全息荧光分子成像系统及方法: 中国, ZL 201310248708.4.
软件著作权
获奖与荣誉
博士研究生国家奖学金
清华大学2013年度优秀博士学位论文一等奖
清华大学优秀博士毕业生
北京市优秀博士毕业生
第二届国际分子影像高峰论坛“白冠仁青年学子奖”二等奖
第一届北京“生物医学工程新星杯”学生学术论文演讲比赛第一名
2008届浙江大学优秀毕业生
浙江省普通高等学校优秀毕业生