张金华

基本信息

教育背景

中国农业大学，生物学院，理学博士

工作经历

2019-现在 北京交通大学 教授 （破格晋升）

2015-2017 美国德州大学MD安德森癌症中心访问学者

2014- 2019 北京交通大学理学院 副教授 

2006 -2014 中科院生物物理研究所感染免疫中心 博士后、副研究员

张金华，北京交通大学，教授，博士生导师。研究方向为肿瘤微环境和肿瘤免疫。

利用基因敲除小鼠结合临床，重点研究肿瘤微环境中成纤维细胞、巨噬细胞、T细胞与肿瘤细胞的相互作用；消化道系统肿瘤如结肠癌、肝癌的发生发展机制；新型免疫抑制分子为靶点的抗肿瘤免疫机制研究；生物来源的新型纳米材料抗感染及抑癌机制等。在Nature Communications, Cell Research、Cancer Research、Advanced Science、Theranostics、Journal of Nanobiotechnology等杂志以第一/通讯作者发表SCI论文40余篇。作为课题负责人承担科技部973子课题1项、国家自然科学基金7项、北京市自然科学基金2项、军委科技委173和开放课题重点项目各1项。

招收生物学硕士和博士研究生，联合培养硕士和博士研究生。欢迎对肿瘤基础研究感兴趣的同学加入团队！

研究方向

• 生物化学与分子生物学
• 细胞生物学
• 物理与交叉学科

招生专业

• 生物学硕士
• 物理学博士

科研项目

1. 国家自然科学基金面上项目，32571089，新型免疫抑制型分子Lypd6促进CD8+T细胞耗竭加速结肠癌发生的分子机制研究，2026.01-2029.12，主持

2. 国家自然科学基金区域创新发展联合基金重点项目，U24A20812，云南两栖爬行动物Cathelicidins免疫调节肽发掘及其抗耐药菌感染的作用机制研究，2025.01-2028.12 参加，合作单位负责人。

3. JW重点项目，XXX的应用研究，2023.01-2025.12，主持。

4. 北京市自然科学基金面上项目，723210，PIK3IP1通过调节CD8+ T细胞代谢促进结肠癌发生的分子机制研究，2023.01-2025.12，主持。

5. JW科技委173项目，XXX在XXX中的作用及应用研究，2021.10-2023.10，主持。

6. 国家自然科学基金面上项目，81972689，肿瘤相关成纤维细胞中Toll样受体信号通路对巨噬细胞的调节及在结肠癌发生中的作用和分子机制研究, 2020.01-2023.12,主持。

7. 国家自然科学基金面上项目，81772497，S100A4在肺癌肿瘤生长中对自噬的作用及分子机制研究，2018/1-2021/12，主持。

8. 973 “炎-癌生物信号交互调控癌进展及阻抑治疗分子机制”项目（2015CB553700）子课题负责人，2015/01-2019/12，主持。

9. 北京市自然科学基金面上项目，成纤维细胞在炎症调节及结肠癌发生中的作用与分子机制研究，2016/01-2018/12，主持。

10. 国家自然科学基金应急管理项目，S100A4在结肠炎相关的肿瘤发生中的作用及分子机制研究，2016/01-2016/12，主持。

11. 北京交通大基本科研业务费，S2015JBM095，100A4阳性细胞在慢性炎症及肿瘤发生中的作用与分子机制研究，2015/01-2016/12，主持。

12. 北京交通大学人才基金，2014RC022，间质成纤维细胞在炎癌转变中的作用及分子机制研究，2014/9-2016/8，主持。

13. 国家自然科学基金面上项目，81370543，S100A4 阳性细胞在肝纤维化中的作用及分子机制研究，2014/01-2017/12，主持。

14. 国家自然科学基金创新基金，81141095、免疫细胞Toll 样受体信号对炎症和肿瘤发生的调节作用和机制，2012/01-2012/12，主持。

15. 国家自然科学基金青年基金，30700287，间质成纤维细胞在肿瘤发生发展过程中的作用，2008/01-2010/12，主持。

16. 中国科学院生物物理研究所博士后专项基金，成纤维细胞对肿瘤的作用及机制，2008/01-2008/12，主持。

17. 中国博士后科学基金，IL4调节肿瘤内新血管形成的机制的研究，2006/01-2006/12，主持。

教学工作

论文/期刊

1. Lypd6b depletion promotes CD8+ T cell-mediated anti-tumor immunity via metabolic reprogramming in colorectal cancer
Ting Liu, Fanxin Zeng, Zuyin Li, Leirong Cheng, Xuanxuan Yan, Haiqiang Chen, Qin Liu, Xue Li, Zhao Li, Jiaheng Yao, Dan Xu, Zhinan Chen, Fengchao Wang, Jun Wang and Jinhua Zhang*
Nature Communications, 2025，Dec.11, online

2. Comprehensive wound healing using ETN@Fe7S8 complex by positively regulating multiple programmed phases
Mengxia Chen, Ting Liu, Xiaonan Wang, Lizeng Gao, Yunqing Cheng, Jing Jiang and Jinhua Zhang*. 
Journal of Nanobiotechnology , 2025; 23:342.

3. Smad4 deficiency in hepatocytes attenuates NAFLD progression via inhibition of lipogenesis and macrophage polarization
Wei Yang, Xuanxuan Yan, Rui Chen, Xin Xin, Shuang Ge, Yongxiang Zhao, Xinlong Yan, Jinhua Zhang*， 
Cell Death & Disease，2025 ；16(1):58. 

4. New insights into T cell metabolism in liver cancer: from mechanism to therapy
Jie Xiao, Ting Liu, Fanxin Zeng，Jinhua Zhang*. 
Cell Death Discovery，2025 ;11(1):118.

5. Hepatocyte-specific Smad4 deficiency inhibits hepatocarcinogenesis by promoting CXCL10/CXCR3-dependent CD8+-T cell-mediated anti-tumor immunity.
Xin Xin, Zhao Li, Xuanxuan Yan, Ting Liu, Zuyin Li, Zhuomiaoyu Chen, Xinlong Yan Fanxin Zeng, Lingling Hou*, Jinhua Zhang*,
Theranostics. 2024,14(15):5853-5868.

6. Smad4 Deficiency in S100A4+ Macrophages Enhances Colitis-associated Tumorigenesis by Promoting Macrophage Lipid Metabolism Augmented M2 Polarization. 
Ting Liu#, Xinyuan Zhang#, Xuanxuan Yan, Leirong Cheng, Xinlong Yan, Fanxin Zeng， Xue Li，Zhinan Chen，Jianchun Gu, Jinhua Zhang*
International Journal of Biological Sciences. 2024, 20(15):6114-6129.  

7. An erythrocyte-templated iron single-atom nanozyme for wound healing
Xiaonan Wang, Ting Liu, Mengxia Chen, Qian Liang, Jing Jiang, Lei Chen, Kelong Fan, Jinhua Zhang,* and Lizeng Gao* 
Advanced Science (Weinh). 2024 Feb;11(6):e2307844.

8. MyD88 in myofibroblasts enhances nonalcoholic fatty liver disease-related hepatocarcinogenesis via promoting macrophage M2 polarization
Yu Liu, Haiqiang Chen, Xuanxuan Yan, Jie Zhang, Zhenzhong Deng, Maosheng Huang, Jianchun Gu, Jinhua Zhang*，
Cell Commun Signal. 2024 Jan 30;22(1):86. 

9. The Immune Regulatory Role of Adenosine in the Tumor Microenvironment
Jianlei Xing, Jinhua Zhang*, Jinyan Wang*，
Int J Mol Sci. 2023 Oct 5;24(19):14928. 

10. MyD88 in myofibroblasts regulates aerobic glycolysis-driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation.
Qi Yuan, Jie Zhang, Yu Liu, Haiqiang Chen, Haiyang Liu, Jinyan Wang, Meng Niu, Lingling Hou, Zhenlong Wu, Zhinan Chen, Jinhua Zhang*. 
Journal of Pathology， 2022 Apr;256(4):414-426.

11. MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization
Zhang J, Liu Y, Chen H, Yuan Q, Wang J, Niu M, Hou L, Gu J, Zhang J.*.
Cell Death & Disease. 2022，Apr 28;13(4):411. 

12. MyD88 in macrophages protects against colitis via inhibiting the activation of NLRP3 inflammasome in epithelial cells.
Shi Liu, Yanmin Wu, Haiqiang Chen, Qi Yuan, Shuang Ge, Lishu Zhang,Lingling Hou, Tian Tian, Jinhua Zhang*.
Genes and Disease, 2022 May 18;10(2):344-347 

13. MyD88 in myofibroblasts enhances colitis-associated tumorigenesis via promoting macrophage M2 polarization.
Qi Yuan, Jianchun Gu, Jie Zhang, Shi Liu, Qinchuan Wang, Tian Tian, Zhinan Chen, and Jinhua Zhang*. 
Cell Reports，2021, 34（5）:108724. 

14. Tumor-associated macrophages (TAMs) in colorectal cancer (CRC): from mechanism to therapy and prognosis,
Hui Wang, Tian Tian, Jinhua Zhang*, 
Int J Mol Sci, 2021, 22, 8470. 

15. S100A4 promotes hepatocellular carcinogenesis by intensifying fibrosis-associated cancer cell stemness.
Yanan Li, Jun Wang, Kun Song, Shuangqing Liu, Huilei Zhang, Chen Ni, Zhihai Qin* and Jinhua Zhang*. 
Oncoimmunology, 2020, 9(1):1725355. 

16. Soluble immune checkpoint-related proteins as predictors of tumor recurrence, survival, and T cell phenotypes in clear cell renal cell carcinoma patients
Qinchuan Wang#, Jinhua Zhang#, Huakang Tu, Dong Liang, David. W. Chang, Yuanqing Ye and Xifeng Wu*，
Journal for ImmunoTherapy of Cancer, 2019, 7（1）:334-343 

17. mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
Tian Tian, Xiaoyi Li and Jinhua Zhang *
Int J Mol Sci.2019 Feb 11;20(3)

18. .A novel m6A reader Prrc2a controls oligodendroglial specification and myelination.
Rong Wu#, Ang Li#, Baofa Sun#, Jian-Guang Sun#, Jinhua Zhang#, Ting Zhang, Yusheng Chen, Yujie Xiao, Yuhao Gao, Qingyang Zhang, Jun Ma, Xin Yang, Yajin Liao, Wei-Yi Lai, Xiaolong Qi, Shukun Wang, Yousheng Shu, Hai-Lin Wang, Fengchao Wang, Yun-Gui Yang and Zengqiang Yuan*
Cell Research, 2019, 29:23–41 

19. S100A4 promotes colon inflammation and colitis-associated colon tumorigenesis. 
Jinhua Zhang*, Shasha Hou, Jianchun Gu, Tian Tian, Qi Yuan, Junying Jia, Zhihai Qin, Zhinan Chen*,
OncoImmunology, 2018 Jun 11;7(8):e1461301.

20. S100A4 blockage alleviates agonisticanti-CD137 antibody-induced liver pathology without disruption of anti-tumor immunity
Jinhua Zhang，Kun Song，Jun Wang，Yanan Li，Shuangqing Liu，Chengliang Dai，Lieping Chen，Shengdian Wang，Zhihai Qin* 
Oncoimmunoloy，2018 Jan 23;7(4):e1296996.  

21. Global and targeted circulating miRNA profiling of colorectal adenoma and colorectal cancer. 
Jinhua Zhang, Gottumakkala S. Raju, David W. Chang, Shu-Hong Lin, Zhinan Chen, Xifeng Wu*. 
Cancer, 2018 ,124(4):785-796 

22. Global and targeted microRNA expression profiling in clear cell renal cell carcinoma tissues potentially links miR-155-5p and miR-210-3p to both tumorigenesis and recurrence,
 Jinhua Zhang, Yuanqing Ye, David W. Chang, Shu-Hong Lin, Maosheng Huang, Nizar M. Tannir, Surena Matin, Jose A. Karam, Christopher G. Wood, Zhinan Chen, Xifeng Wu*, 
American Journal of Pathology, 2018, Nov;188(11):2487-2496.  

23. S100A4 promotes lung tumordevelopment through β-catenin pathwaymediated autophagy inhibition.
 Shasha Hou, Tian Tian, Dianwen Qi, Kaiji Sun, Qi Yuan, Ziling Wang, Zhihai Qin, ZhenlongWu, Zhinan Chen and Jinhua Zhang*.
 Cell Death and Disease, 2018, 9(3):277. 

24. S100A4 promotes liver fibrosis via activation of hepatic stellate cells.
Lin Chen,  Jie Li, Jinhua Zhang, Chengliang Dai, Xiaoman Liu, Jun Wang , Zhihai Qin*. 
Journal of Hepatology, 2015,62:156–164 

25. Fibroblast-Specific Protein 1/S100A4–Positive Cells Prevent Carcinoma through Collagen Production and Encapsulation of Carcinogens, 
Jinhua Zhang, Lin Chen, Xiaoman Liu and Zhihai Qin*,
Cancer Research, 2013, 73:2770-2781 

26. FSP1+ fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. 
Jinhua Zhang, Lin Chen, Mingjie Xiao, Chunhui Wang and Zhihai Qin,
American Journal of Pathology, 2011, 178:382-390

27. PI4KIIα is a novel regulator of tumor growth by its action on angiogenesis and HIF-1α regulation. 
Jiangmei Li, Yu Lu, Jinhua Zhang, Hua Kang, Zhihai Qin and Chang Chen,
Oncogene, 2010, 29:2550-2559 

28. IFNγ promotes papilloma development by up-regulating Th17-associated inflammation.
Mingjie Xiao, Chunhui Wang, Jinhua Zhang, Zhiguang Li, Xueqiang Zhao and Zhihai Qin, 
Cancer Research, 2009, 69:2010-2017 

29. Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis.
Zhiguang Li, Jing Jiang, Zibing Wang, Jinhua Zhang, Mingjie Xiao, Chunhui Wang and Zhihai Qin,
Cancer Research, 2008, 68:8687-8694

30. LIM homeodomain proteins Islet-1 and Lim-3 expressions in the developing pineal gland of chick embryo by immunohistochemistry. 
Jinhua Zhang, Jiali Liu, Yingjie Wu and Sheng Cui. 
Journal of Pineal Research, 2006, 41:247-254

专著/译著

专利

软件著作权

获奖与荣誉

社会兼职

中国细胞生物学学会细胞工程与转基因动物分会 常务委员

中国抗癌协会肿瘤分子医学分会  委员

中国转化医学联盟细胞生物学分会 委员