张金华
博士、教授
基本信息
| 办公电话：18910876157 | 电子邮件： zhangjh@bjtu.edu.cn |
| 通讯地址：北京市海淀区上园村3号，北京交通大学理学院生命科学与生物工程研究院2215室 | 邮编：100044 |
教育背景
北京交通大学，教授，博士生导师。研究方向为肿瘤微环境和肿瘤免疫。
主要研究肿瘤微环境中成纤维细胞、巨噬细胞、T细胞等间质细胞在肺癌、结肠癌和肝癌发生发展中的作用及分子机制。利用多种基因敲除及条件敲除小鼠，采用多种肿瘤模型，结合临床研究：
（1）结肠炎和结肠癌发生发展的分子机制。
（2）肝纤维化、酒精肝、脂肪肝、肝癌发生发展的分子机制。
（3）免疫抑制分子抗肿瘤免疫的分子机制。
（4）生物来源的新型纳米材料抗感染及抑癌机制。
在Cancer Research、Cell Reports、Journal of Pathology、Cell Research等杂志以第一/通讯作者发表SCI论文30余篇。主持国家科技部 “973”子课题1项，国家自然科学基金6项，JW科技委173 1项，JW后勤重点项目1项，北京自然科学基金面上项目2项。
工作经历
2019.12-现在 北京交通大学 教授 （破格晋升）
2015.12-2017.6 美国德州大学MD安德森癌症中心访问学者
2014.7- 2019.11北京交通大学 副教授
2006.7-2014.6中科院生物物理研究所感染免疫中心 博士后、副研究员
研究方向
- 生物化学与分子生物学
- 细胞生物学
- 物理与交叉学科
招生专业
- 生物学硕士
- 物理学博士
科研项目
1. JW重点项目，XXX的应用研究，2023.01-2025.12，197万，主持。
2. 北京市自然科学基金面上项目，723210，PIK3IP1通过调节CD8+ T细胞代谢促进结肠癌发生的分子机制研究，2023.01-2025.12，20万，主持。
3. JW科技委173项目，XXX在XXX中的作用及应用研究，2021.10-2023.10，70万，主持。
4. 国家自然科学基金面上项目，81972689，肿瘤相关成纤维细胞中Toll样受体信号通路对巨噬细胞的调节及在结肠癌发生中的作用和分子机制研究, 2020.01-2023.12, 55万，主持。
5. 国家自然科学基金面上项目，81772497，S100A4在肺癌肿瘤生长中对自噬的作用及分子机制研究，2018/1-2021/12，55万，主持。
6. 973 “炎-癌生物信号交互调控癌进展及阻抑治疗分子机制”项目（2015CB553700）子课题负责人，2015/01-2019/12，115.5万，主持。
7. 北京市自然科学基金面上项目，成纤维细胞在炎症调节及结肠癌发生中的作用与分子机制研究，2016/01-2018/12，18万，主持。
8. 国家自然科学基金应急管理项目，S100A4在结肠炎相关的肿瘤发生中的作用及分子机制研究，2016/01-2016/12，10万，主持。
9. 北京交通大基本科研业务费，S 2015JBM095，100A4阳性细胞在慢性炎症及肿瘤发生中的作用与分子机制研究，2015/01-2016/12，7万，主持。
10. 北京交通大学人才基金，2014RC022，间质成纤维细胞在炎癌转变中的作用及分子机制研究，2014/9-2016/8，15万，主持。
11. 国家自然科学基金面上项目，81370543，S100A4 阳性细胞在肝纤维化中的作用及分子机制研究，2014/01-2017/12，70万，主持。
12. 国家自然科学基金创新基金，81141095、免疫细胞Toll 样受体信号对炎症和肿瘤发生的调节作用和机制，2012/01-2012/12，10万，主持。
13. 国家自然科学基金青年基金，30700287，间质成纤维细胞在肿瘤发生发展过程中的作用，2008/01-2010/12，17万，主持。
14. 中国科学院生物物理研究所博士后专项基金，成纤维细胞对肿瘤的作用及机制，2008/01-2008/12，6.4万，主持。
15. 中国博士后科学基金，IL4调节肿瘤内新血管形成的机制的研究，2006/01-2006/12，3万，主持。
教学工作
研究生：《分子免疫学》 《实验动物学》本科生：《生命科学纵横》
论文/期刊
1. Xiaonan Wang, Ting Liu, Mengxia Chen, Qian Liang, Jing Jiang, Lei Chen, Kelong Fan, Jinhua Zhang,* and Lizeng Gao*An erythrocyte-templated iron single-atom nanozyme for wound healing, Advanced Science (Weinh). 2024 Feb;11(6):e2307844.
2. Yu Liu, Haiqiang Chen, Xuanxuan Yan, Jie Zhang, Zhenzhong Deng, Maosheng Huang, Jianchun Gu, Jinhua Zhang*，MyD88 in myofibroblasts enhances nonalcoholic fatty liver disease-related hepatocarcinogenesis via promoting macrophage M2 polarization，Cell Commun Signal. 2024 Jan 30;22(1):86.
3. Qi Yuan, Jie Zhang, Yu Liu, Haiqiang Chen, Haiyang Liu, Jinyan Wang, Meng Niu, Lingling Hou, Zhenlong Wu, Zhinan Chen, Jinhua Zhang*. MyD88 in myofibroblasts regulates aerobic glycolysis-driven hepatocarcinogenesis via ERK-dependent PKM2 nuclear relocalization and activation. Journal of Pathology， 2022 Apr;256(4):414-426.
4. Zhang J, Liu Y, Chen H, Yuan Q, Wang J, Niu M, Hou L, Gu J, Zhang J.* MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization. Cell Death & Disease. 2022，Apr 28;13(4):411.
5. Shi Liu, Yanmin Wu, Haiqiang Chen, Qi Yuan, Shuang Ge, Lishu Zhang,Lingling Hou, Tian Tian, Jinhua Zhang*. MyD88 in macrophages protects against colitis via inhibiting the activation of NLRP3 inflammasome in epithelial cells. Genes and Disease, 2022 May 18;10(2):344-347
6. Yukun Li1, Miaomiao Wei1, Qi Yuan, Yu Liu, Tian Tian, Lingling Hou1, Jinhua Zhang*. MyD88 in hepatic stellate cells promotes the development of alcoholic fatty liver via the AKT pathway. Journal of Molecular Medicine，2022, Jul;100(7):1071-1085.
7. Wei M, Yan X, Xin X, Chen H, Hou L, Zhang J. Hepatocyte-Specific Smad4 Deficiency Alleviates Liver Fibrosis via the p38/p65 Pathway. Int. J. Mol. Sci. 2022, 23, 11696.
8. Qi Yuan, Jianchun Gu, Jie Zhang, Shi Liu, Qinchuan Wang, Tian Tian, Zhinan Chen, and Jinhua Zhang*. MyD88 in myofibroblasts enhances colitis-associated tumorigenesis via promoting macrophage M2 polarization. Cell Reports，2021, 34（5）:108724.
9. Shuang Ge, Wei Yang, Haiqiang Chen, Qi Yuan, Shi Liu, Yongxiang Zhao 1, and Jinhua Zhang*. MyD88 in macrophages enhances liver fibrosis by activation of NLRP3 inflammasome in HSCs. Int. J. Mol. Sci. 2021, 22, 12413.
10. Hui Wang, Tian Tian, Jinhua Zhang*, Tumor-associated macrophages (TAMs) in colorectal cancer (CRC): from mechanism to therapy and prognosis, Int J Mol Sci, 2021, 22, 8470.
11. Yanan Li, Jun Wang, Kun Song, Shuangqing Liu, Huilei Zhang, Chen Ni, Zhihai Qin and Jinhua Zhang*. S100A4 promotes hepatocellular carcinogenesis by intensifying fibrosis-associated cancer cell stemness. Oncoimmunology, 2020, 9(1):1725355.
12. Qinchuan Wang#, Jinhua Zhang#, Huakang Tu, Dong Liang, David. W. Chang, Yuanqing Ye and Xifeng Wu*，Soluble immune checkpoint-related proteins as predictors of tumor recurrence, survival, and T cell phenotypes in clear cell renal cell carcinoma patients，Journal for ImmunoTherapy of Cancer, 2019, 7（1）:334-343
13. Qi Yuan, Shasha Hou, Junfeng Zhai, Tian Tian, Yingjie Wu, Zhenlong Wu, Jinsheng He, Zhinan Chen, Jinhua Zhang*. S100A4 promotes inflammation but suppresses lipid accumulation via the STAT3 pathway in chronic ethanol-induced fatty liver. Journal of Molecular Medicine，2019, 97(10):1399-1412.
14. Tian Tian, Xiaoyi Li and Jinhua Zhang * mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy .Int J Mol Sci.2019 Feb 11;20(3)
15. Rong Wu#, Ang Li#, Baofa Sun#, Jian-Guang Sun#, Jinhua Zhang#, Ting Zhang, Yusheng Chen, Yujie Xiao, Yuhao Gao, Qingyang Zhang, Jun Ma, Xin Yang, Yajin Liao, Wei-Yi Lai, Xiaolong Qi, Shukun Wang, Yousheng Shu, Hai-Lin Wang, Fengchao Wang, Yun-Gui Yang and Zengqiang Yuan. A novel m6A reader Prrc2a controls oligodendroglial specification and myelination. Cell Research, 2019, 29:23–41
16. Jinhua Zhang*, Shasha Hou, Jianchun Gu, Tian Tian, Qi Yuan, Junying Jia, Zhihai Qin, Zhinan Chen*, S100A4 promotes colon inflammation and colitis-associated colon tumorigenesis. OncoImmunology, 2018 Jun 11;7(8):e1461301.
17. Jinhua Zhang，Kun Song，Jun Wang，Yanan Li，Shuangqing Liu，Chengliang Dai，Lieping Chen，Shengdian Wang，Zhihai Qin* ， S100A4 blockage alleviates agonisticanti-CD137 antibody-induced liver pathology without disruption of anti-tumor immunity，Oncoimmunoloy，2018 Jan 23;7(4):e1296996.
18. Jinhua Zhang, Gottumakkala S. Raju, David W. Chang, Shu-Hong Lin, Zhinan Chen, Xifeng Wu*. Global and targeted circulating miRNA profiling of colorectal adenoma and colorectal cancer. Cancer, 2018 ,124(4):785-796
19. Jinhua Zhang, Yuanqing Ye, David W. Chang, Shu-Hong Lin, Maosheng Huang, Nizar M. Tannir, Surena Matin, Jose A. Karam, Christopher G. Wood, Zhinan Chen, Xifeng Wu*, Global and targeted microRNA expression profiling in clear cell renal cell carcinoma tissues potentially links miR-155-5p and miR-210-3p to both tumorigenesis and recurrence, American Journal of Pathology, 2018, Nov;188(11):2487-2496.
20. Shasha Hou, Tian Tian, Dianwen Qi, Kaiji Sun, Qi Yuan, Ziling Wang, Zhihai Qin, ZhenlongWu, Zhinan Chen and Jinhua Zhang*. S100A4 promotes lung tumordevelopment through β-catenin pathwaymediated autophagy inhibition. Cell Death and Disease, 2018, 9(3):277.
21. Shasha Hou, Ying Jiao, Qi Yuan, Junfeng Zhai, Tian Tian, Kaiji Sun, Zhinan Chen, Zhenlong Wu, Jinhua Zhang*. S100A4 protects mice from high-fat diet-induced obesity and inflammation. Laboratory investigation, 2018, 98(8):1025-1038.
22. Yingjie Wu#, Jinhua Zhang#, Yinghe Qin, S100A4 promotes the development of lipopolysaccharide-induced mouse endometritis, Biology of Reproduction，2018 Nov 1;99(5):960-967
23. Tian Tian, Ziling Wang, and Jinhua Zhang*，Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies, Oxidative medicine and cellular longevity, 2017;2017:4535194.
24. Jinhua Zhang*, Ying Jiao, Shasha Hou, Tian Tian, Qi Yuan, Huaijie Hao, Zhenlong Wu, Xuexiang Bao. S100A4 contributes to colitis development by increasing the adherence of Citrobacter rodentium in intestinal epithelial cells. Scientific Reports, 2017 Sep 21;7(1):12099
25. Jianchun Gu，Dong Liang，Jeanne A Pierzynski，Yuanqing Ye，Jinhua Zhang， Jaffer A.Ajani，Xifeng Wu ， D-mannose: a novel prognostic biomarker for patients with esophageal adenocarcinoma，Carcinogenesis，2017.01.06，38（2）：162~167
26. Lin Chen, Jie Li, Jinhua Zhang, Chengliang Dai, Xiaoman Liu, Jun Wang , Zhihai Qin. S100A4 promotes liver fibrosis via activation of hepatic stellate cells. Journal of Hepatology, 2015,62:156–164
27. Jinhua Zhang, Lin Chen, Xiaoman Liu and Zhihai Qin*, Fibroblast-Specific Protein 1/S100A4–Positive Cells Prevent Carcinoma through Collagen Production and Encapsulation of Carcinogens, Cancer Research, 2013, 73:2770-2781
28. Jinhua Zhang, Lin Chen, Mingjie Xiao, Chunhui Wang and Zhihai Qin, FSP1+ fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. American Journal of Pathology, 2011, 178:382-390
29. Jiangmei Li, Yu Lu, Jinhua Zhang, Hua Kang, Zhihai Qin and Chang Chen, PI4KIIα is a novel regulator of tumor growth by its action on angiogenesis and HIF-1α regulation. Oncogene, 2010, 29:2550-2559
30. Zibing Wang, Jing Jiang, Zhiguang Li, Jinhua Zhang, Hui Wang and Zhihaiqin, A myeloid cell population induced by Freund’s adjuvant suppresses T cell-mediated anti-tumor immunity. Journal of immunotherapy, 2010, 33:167-177
31. Jing Jiang, Zibing Wang, Zhiguang Li, Jinhua Zhang, Xiaopu Zhao and Zhihai Qin, Early exposure of high-dose interleukin-4 to tumor stroma reverses myeloid cell-mediated T-cell suppression. Gene therapy, 2010, 17: 991-999
32. Mingjie Xiao, Chunhui Wang, Jinhua Zhang, Zhiguang Li, Xueqiang Zhao and Zhihai Qin, IFNγ promotes papilloma development by up-regulating Th17-associated inflammation. Cancer Research, 2009, 69:2010-2017
33. Wu YJ, Chen DW, Liu JL, Zhang JH, Luo HS, Cui S. Estradiol promotes pituitary cell proliferation and gonadotroph differentiation at different doses and with different mechanisms in chick embryo. Steroids, 2009, 74:441-448
34. Zhiguang Li, Jing Jiang, Zibing Wang, Jinhua Zhang, Mingjie Xiao, Chunhui Wang and Zhihai Qin, Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis. Cancer Research, 2008, 68:8687-8694
35. Xuejun Yuan, Yuqin He, Haoshu Luo, Jinhua Zhang, Sheng Cui. Expression of androgen receptor and its co-localization with estrogen receptor-alpha in the developing pituitary gland of sheep fetus. Histochemistry and Cell Biology, 2007, 127: 423-432
36. Jinhua Zhang, Jiali Liu, Yingjie Wu and Sheng Cui. LIM homeodomain proteins Islet-1 and Lim-3 expressions in the developing pineal gland of chick embryo by immunohistochemistry. Journal of Pineal Research, 2006, 41:247-254
专著/译著
专利
软件著作权
获奖与荣誉
1.2017年 北京交通大学理学院 贡献奖
2.2010年 中国科学院生物物理研究所优秀博士后论文
3.2007年 抑制血管新生是抗肿瘤免疫反应的主要效应机制， 北京市科学技术进步奖，三等奖，排名第四
4.2006年 中国科学院王宽诚博士后工作奖励基金
5.2006年中国博士后基金二等奖
社会兼职
中国细胞生物学学会细胞工程与转基因动物分会 委员
中国转化医学联盟细胞生物学分会 委员
中国抗癌协会会员
美国癌症协会（AACR）会员