成喜雨

博士、教授

基本信息

办公电话:010-51684351-808 电子邮件: xycheng@bjtu.edu.cn
通讯地址:北京市海淀区上园村3号 北京交通大学物理学院 生命科学与生物工程研究院 邮编:100044

教育背景

  2013.06~至今            北京交通大学               现任 教授/博士研究生导师

  2011.06~2013.05       新加坡国立大学           Research scientist

  2011年,                   中国科学院 过程工程所(生化工程国家重点实验室) 生物化工 博士 (北京科技大学、湖南科技大学 硕士/学士

成喜雨,北京交通大学 生命科学与生物工程研究院,教授/博导,入选北京交通大学首批“青年英才”计划。主持和参与国家自然科学基金、教育部联合基金、北京市自然科学基金、JW科技委、Singapore-GSK国际合作项目、中科院知识创新工程等项目20余项。已在Advanced Functional Materials IF 19.924)、Science of the Total Environment IF 10.753)、 Ecotoxicology and Environmental Safety IF 7.129Applied EnergyIF 11.2Bioresource Technology IF 11.4)、合成生物学》、前瞻科技国内外高水平学术期刊发表论文近60篇,SCI论文 h-因子为16, 参与出版中英文专著共3本,申请发明专利9项

专注 生物材料与合成生物 研究,主要包括

(1) 仿生抗肿瘤剂型工程细菌磁小体/囊泡等生物纳米基肿瘤联合治疗生物纳米+合成生物)(中国科学院 生化工程国家重点实验室 研究生联合培养项目);

(2) 系统生物与合成生物环境/肠道微生物组;细胞工厂;生物安全;环境与健康多组学+微生物工程+合成生物

(3) 人因工程与生保系统等:受控生态系统、人因安全监测防控等多组学+AI+微生物工程)。


招生背景需求生物学(熟悉合成生物、基因工程、代谢工程优)、生物信息熟悉多组学、AI数学/计算机基础好优)、化学/材料/环境/信息等相关专业;有意交大读研者请邮件联系:xycheng@bjtu.edu.cn 【另:中科院 杰青(Cell Nature Science子刊论文10+篇)、院士团队招聘 2024 AI、合成生物、生物信息 方向优秀硕士博士,有推免资格本科生可邮箱联系咨询】

优秀毕业生可推荐去中科院、清华、北大、军事医学科学院、天大北航、北理、北化、海外等优秀团队读博




工作经历

  2013.06~至今            北京交通大学               现任 教授/博导


研究方向

  • 生物化学与分子生物学
  • 生物信息学
  • 物理与交叉学科

招生专业

  • 生物学硕士
  • 物理学博士

科研项目

**北京市自然科学基金面上项目细菌磁小体生物合成及其多效协同抗肿瘤研究,2023.01~2025.12,主持

**国家级纵向项目,****细胞工厂2022.03~2023.12,主持

**国家重点研发计划高原山地型奶牛本土适应性遗传机制研究. 2022.11~2026.12,参与

**国家级纵向项目,基于纳米孔测序和CRISPR的****2021.12~2023.12,主持

**国家级纵向项目(重点项目),****关键技术2021.12~2024.12,子课题

**横向合作课题, 藻类小试培养反应器装置, 2022.01~2022.07,主持

**中国轻工业重点实验室课题高效除臭菌的筛选鉴定及复合菌群的构建2021.07~2022.07,主持

**国家级纵向项目,****系统研究2019.07~2022.06,第二

**中国轻工业重点实验室课题,两级弱酸/碱预处理增强轻工固废转化研究,2020.07~2021.07,主持

**中国轻工业重点实验室课题,轻工生物质热水预处理和酶解中纤维解聚机理及选择性调控,2019.07~2020.07,主持

**中央高校基本科研业务费,纤维废弃物生物加工中纤维降解多尺度问题研究,2017.01~2019.01,主持

**北京市自然科学基金面上项目,成纤维细胞在炎症调节及结肠癌发生中的作用与分子机制研究,2016.1~2018.12,参与

**国家自然科学基金S100A4在结肠炎相关的肿瘤发生中的作用及分子机制研究,2016.1~2018.12,参与

**国家自然科学基金 (No. 21306009), 高温菌共培养发酵木质纤维原料产氢过程加强机制的蛋白质组学研究, 2014.01~2016.12,主持

**中央高校基本科研业务费 (2015JBM108), 重金属镉污染损害人体健康及基准剂量研究, 2015.01~2016.12, 主持

**北京交通大学人才基金(2014RC037), 重金属镉致人体健康损害的监测与评价研究, 2014.10~2016.09,  主持

**十二五国家科技支撑计划子任务,典型地区环境污染物相关人群生物监测技术(2013BAI12B00,2013.01~2015.12,参与

**横向合作课题(S14L00170), 白银市四龙镇人群尿样采集及镉含量检测, 2014.07~2014.12,  主持

**GSK-Singapore 生物制药项目 (R279-000-330-592)2011.06~2013.04,参与

**中科院知识创新工程项目(KGCX2-YW-337),2008~2011,参与

教学工作

**本科生课程《生物工程概论》;《影视与生化科技》;《理学之美》;《工科化学》;能源、环境与医药生物技术概论》

**研究生课程《生物工程》;《生物制药工程》

论文/期刊

[52] Xiyu Cheng*, Abdur Rahim Khan, Karima EL Karrach, Feng Wang. Environmental bioremediation: application of enzymes and microbes. Frontiers in Bioengineering and Biotechnology, 2024【*通讯】
[51] Xiaoyu Cui, Zhe Zhang*, Bo Zhao, Xiyu Cheng and zhimei Qi, "Structural Characterization and Optical properties of Perovskite Crystals Based on Micro-Hyperspectral Imaging Sensor," IEEE Sensors Journal, 2023, Doi:10.1109/JSEN.2023.3330162. 【LHJJ】
[50] Xinyi Li, Huang J, Kang Y, Xiyu Cheng, Yan Qiong, Zhang L, Fan J, Xu Hanli. Cancer Stem Cell Biomarkers in the Nervous System: A literature Review. Frontiers in Bioscience Landmark. 2023. (Accepted)【LHJJ】
[49] 晏 琼†,张金磊†,冯 可,李环宇,李玥,成喜雨*. 地外可循环生保系统关键生物技术现状与发展建议. 《前瞻科技》2024年第1期【*通讯】
[48] Hanli Xu, Huixia Gao, Chanjuan Wang, Xiyu Cheng, Zhigang Li, Cui Lei, XiaoTong Huang, Weijing Li, Zhixia Yue, Shuo Tian, Xiaoxi Zhao, Tianlin Xue,  Tianyu Xing, Jun Li, Ying Wang, Yanlong Duan#, Tianyou Wang#, Ruidong Zhang#. Optical Genome Mapping Reveals novel Structural Variants in Lymphoblastic lymphoma. Leukemia Research, 2024【LHJJ】

[47] Yaping Sun, Xiaoyu Liu,Wenxuan Li, Xinning Wang, Xiaoyue Zhong, Yifan Gao, Hanli Xu, Honggang Hu, Lishu Zhang, Xiyu Cheng*, Qiong Yan*. The regulatory metabolic networks of the Brassica campestris L. hairy roots in response to cadmium stress revealed from proteome studies combined with a transcriptome analysis. Ecotoxicology and Environmental Safety, 2023, 263: 115214.【*通讯】 一区 SCI(IF 7.1)

[46] Feng Cao, Xing Lv*, Yixuan Zhou, Xiyu Cheng*. Modified SEIAR infectious disease model for Omicron variants spread dynamics. Nonlinear Dynamics, 2023, 111: 14597–14620【*通讯】

[45] Xiaoyu Liu, Wenxuan Li, Menghua Wang, Yushen Cao, Teng Zhang, Honggang Hu, Xiyu Cheng*, Qiong Yan. Establishment of hairy root system of transgenic IRT1 brassica campestris L. and preliminary study of its effect on cadmium enrichment. International Journal of Phytoremediation 2023,25(11):1455-1462【*通讯】

[44]  史硕博, 张翀, 成喜雨, 邢新会. 挑战造物主:合成生物学使能工具. 合成生物学,doi: 10.12211/2096-8280.2023-012

[43]  Liyang Wang, Jinyu Fu, Guang Cai, Xiyu Cheng, Di Zhang, Shuobo Shi,Yueping Zhang. Rapid and Visual RPA-Cas12a Fluorescence Assay for Accurate Detection of Dermatophytes in Cats and Dogs. BIOSENSORS-BASEL,2022,12 (8) :636.

[42]  Chunming Xu, Lingqiang Kong, Hanfang Gao, Xiyu Cheng, Xiumin Wang. A review of current bacterial resistance to antibiotics in food animals. Frontiers in Microbiology, 2022, 13, 822689.

[41]  晏琼,刘晓宇,虞昊安,李翎慈,刘潇漪,张育新,戴昊鸣,陈斯琳,成喜雨*. 植物无土栽培技术研究进展. 中国农业大学学报,2022, 5: 1-11. 【*通讯】

[40]  Bo Tian, Jia-Heng Yao, Xu Lin, Wan-Qiang Lv, Lin-Dong Jiang, Zhuo-Qi Wang, Jie Shen, Hong-Mei Xiao, Hanli Xu, Lu-Lu Xu, Xiyu Cheng, Hui Shen, Chuan Qiu, Zhe Luo, Lan-Juan Zhao, Qiong Yan, Hong-Wen Deng* and Li-Shu Zhang*. Metagenomic study of the gut microbiota associated with cow milk consumption in Chinese peri-/postmenopausal women. Frontiers in Microbiology, 2022, 13: 957885.

[39]  Shanshan Zhao, Cheng Qiu, Tangwei Zhang, Xiangyu Hu, Yan Zhao, Xiyu Cheng, Yuxuan Ma, Mengjie Qie,Chang Chen. Effects of Fertilizer on the Quality and Traceability of Tibet highland Barley (Hordeum vulgare L.): A Diagnosis Using Nutrients and Mineral Elements. Foods, 2022, 11(21): 3397.

[38] Xiyu Cheng*, Ying Luo, Yifan Gao, Shen Li, Chunming Xu, Shangyuan Tang, Yongkun Yang, Zehua Zhang, He Jiang, Hanli Xu, Shuobo Shi, Qiong Yan. Surfactant-assisted alkaline pretreatment and enzymatic hydrolysis of Miscanthus sinensis for enhancing sugar recovery with a reduced enzyme loading. Frontiers in Bioengineering and Biotechnology, 2022, 10: 918126.【*通讯】

[37] Peng Ye, Feng Li, Jiale Zou, Ying Luo, ......, Xiyu Cheng*, Guanghui Ma*(马光辉), and Wei Wei*魏炜. In situ generation of gold nanoparticles on bacteria-derived magnetosomes for imaging-guided starving/chemodynamic/photothermal synergistic therapy against cancer. Advanced Functional Materials , 2022 32: 2110063 【*通讯】一区 SCI(IF 19.9)【他引20次】
[36] Chun-Ming Xu, Yi-Fan Gao, Shan-Shan He, Kun Luo, Qiong Yan, Xiyu Cheng*. Improved sugar recovery from enzymatic hydrolysis of Miscanthus sinensis by surfactant-mediated alkaline pretreatment. Biomass Conversion and Biorefinery, 2021,4: 1-8【*通讯】
[35] Tianzhen Zhang,Yuqing Shen, Senjia Zhang, Zexiong Xie, Xiyu Cheng, Wenchao Li, Cheng Zhong. Monosaccharide removal and effects of Komagataeibacter xylinus fermentation on antioxidant capacity and flavor profile of Chinese wolfberry juice. Journal of Food Processing and Preservation, 2021, 45 (10): e15800.
[34] Peng Ye, Menghua Wang, Teng Zhang, Xiaoyu Liu, He Jiang, Yaping Sun, Xiyu Cheng*, Qiong Yan*. enhanced cadmium accumulation and tolerance in transgenic hairy roots of Solanum nigrum L. expressing iron-regulated transporter gene IRT1. Life-Basel, 2020, 10: 324.【*通讯】【他引9次】
[33] Lingci Li, Peng Ye, Mengyu Chen, Shangyuan Tang, Ying Luo, Yifan Gao, Qiong Yan*, Xiyu Cheng*. A two-step ferric chloride and dilute alkaline pretreatment for enhancing enzymatic hydrolysis and fermentable sugar recovery from Miscanthus sinensis. Molecules, 2020, 25(8): 1843.【*通讯】
[32] Shangyuan Tang, Yushen Cao, Chunming Xu, Yue Wu, Lingci Li, Peng Ye, Ying Luo, Yifan Gao, Yonghong Liao, Qiong Yan*, Xiyu Cheng*. One-step or two-step acid/alkaline pretreatments to improve enzymatic hydrolysis and sugar recovery from Arundo Donax L. Energies, 2020, 13,948. 【*通讯】
[31] Yaping Sun , Qianyun Lu, Yushen Cao, Menghua Wang, Xiyu Cheng* and Qiong Yan *. Comparative Transcriptome Analysis of the Molecular Mechanism of the Hairy Roots of Brassica campestris L. in Response to Cadmium Stress. International Journal of Molecular Sciences, 2020, 21, 180.【通讯】【他引20次】
[30] Shangyuan Tang, Chunming Xu, Linh Tran Khanh Vu, Sicheng Liu, Peng Ye, Lingci Li, YuxuanWu, Mengyu Chen, Yao Xiao, Yue Wu, Yining Wang, Qiong Yan, Xiyu Cheng. Enhanced enzymatic hydrolysis of Pennisetum alopecuroides by dilute acid, alkaline and ferric chloride pretreatments. Molecules 2019, 24, 1715.【*通讯】
[29] Shen Ke, Xiyu Cheng,  Jieying Zhang, et al. Estimation of benchmark dose of urinary cadmium as the reference level for renal dysfunction: A large sample study in five cadmium polluted areas in China. BMC Public Health, 2015, 15: 656. 【他引32次】
[28] Shen Ke 1, Xiyu Cheng 1, Li Hao, et al. Body burden of cadmium and its related factors: a large-scale survey in China. Science of the Total Environment. 2015, 511: 649-654. 【1:共一】

[27] Shen Ke, Ke Qin-Mei, Jia Wen-Jing, Xiyu Cheng, et al. Benchmark dose estimation for cadmium-induced renal effects based on a large sample population from five Chinese provinces. Biomedical Environment Science 2015; 28(5): 70-73.

[26] Shen Ke 1, Xiyu Cheng 1, Zhang Ni, et al. Cadmium concentrations of rice from various polluted areas of China and potential risks to human health. Environmental Monitoring and Assessment 2015; 187(7): 408(1-11)【1:共一】【他引79次】

[25] Xiyu Cheng*,  Cheng Zhong. Effects of Feed to Inoculum Ratio, Co-digestion and pretreatment on biogas production from anaerobic digestion of cotton stalk. Energy Fuels, 2014, 28 (5): 3157-3166. JCR二区【*通讯】【他引39次】

[24] Xiyu Cheng, Yen-Wah Tong, Kai-Chee Loh. An immersed hollow fiber membrane bioreactor for enhanced biotransformation of indene to cis-indandiol using Pseudomonas putida. Biochemical Engineering Journal, 2014, 87: 1–7.

[23] Xiyu Cheng, Chunzhao Liu. Enhanced coproduction of hydrogen and methane from cornstalks by a three-stage anaerobic fermentation process integrated with alkaline hydrolysis. Bioresource Technology 2012, 104: 373–379. 一区 SCI【他引47次】

[22] Xiyu Cheng, Chunzhao Liu. Fungal pretreatment enhances hydrogen production via thermophilic fermentation of cornstalk. Applied Energy 2012, 91(1): 1-6.一区 SCI

[21] Xiyu Cheng, Qian Li, Chunzhao Liu. Coproduction of hydrogen and methane via anaerobic fermentation of cornstalk waste in continuous stirred tank reactor integrated with up-flow anaerobic sludge bed. Bioresource technology, 2012, 114: 327-333. 一区 SCI【他引39次】

[20] Xiyu Cheng, Chunzhao Liu. Hydrogen production via thermophilic fermentation of cornstalk by Clostridium thermocellum. Energy Fuels 2011, 25(4): 1714-1720. 他引46次

[19] Chunzhao Liu, Xiyu Cheng. Improved hydrogen production via thermophilic fermentation of corn stover by microwave-assisted acid pretreatment, International Journal of Hydrogen Energy, 2010, 35(17): 8945-8952. - JCR一区他引76次

[18] Xiyu Cheng, Chunzhao Liu. Enhanced biogas production from herbal-extraction process residues by microwave-assisted alkaline pretreatment. Journal of Chemical Technology & Biotechnology2010, 85(1): 127-131.

[17] Chunzhao Liu, Xiyu Cheng. Microwave-assisted acid pretreatment for enhancing biogas production from herbal-extraction process residue. Energy & Fuels, 2009, 23(12): 6152-6155.

[16] Chunzhao Liu, Xiyu Cheng. Enhancement of phenylethanoid glycosides biosynthesis in cell cultures of Cistanche deserticola by osmotic stress. Plant Cell Reports, 2008, 27(2): 357-362.

[15] Xiyu Cheng, Hua-Ying Zhou,  Xin Cui, et al. Improvement of phenylethanoid glycosides biosynthesis in Cistanche deserticola cell suspension cultures by chitosan elicitor. Journal of Biotechnology2006, 121(2): 253-260.

[14] Xiyu Cheng, Bin Guo, Hua-Ying Zhou, et al. Repeated elicitation enhances phenylethanoid glycosides accumulation in cell suspension cultures of Cistanche deserticola. Biochemistry Engineering Journal, 2005, 24(3): 203-207.

[13] Xiyu Cheng, Tao Wei Tao, Bin Guo et al. Cistanche deserticola cell suspension cultures: phenylethanoid glycosides biosynthesis and antioxidant activity. Process Biochemistry, 2005, 40(9): 3119-3124.

[12] 成喜雨,王静,柯屾. 原位吸附浸没式膜生物反应器催化制备茚二醇. 生物加工过程,2014, 12(3): 1-6.

[11] 成喜雨,李强,王静,钟成. 典型秸秆废弃物与猪粪共发酵过程碳氮比的影响研究. 可再生能源,2014, 32(6): 848-853.

[10] 成喜雨,李超,王静,钟成. 预处理对秸秆废弃物沼气发酵的影响研究. 可再生能源,2014, 32(4): 524-528.

[9] 贾闻婧,柯屾,成喜雨,李浩,张妮,张洁莹,晏琼,陈志南. 沈阳市郊某区域人群尿镉含量及相关肾功能指标调查. 中国公共卫生, 2014, 30: 28-30. 

[8] 李浩,柯屾,成喜雨,毛吉祥,陈志南. 结构方程模型在环境健康管理研究中的应用. 环境与健康杂志, 2014, 31(7): 606-609.

[7] 成喜雨,李超,李兵,王冰,田云,郑明霞,沈绍传.物料产甲烷潜力分析技术及设备评述.可再生能源,2013, 31(5): 72-79.

[6] 成喜雨,庄国强,苏志国,刘春朝.沼气发酵过程研究进展.过程工程学报,2008,8:607-615. 

[5] 成喜雨,何姗姗,倪文,刘春朝.植物组织培养生物反应器技术研究进展.生物加工过程, 2003,1:18-22,38.

[4] 成喜雨,郭斌,倪文,刘春朝.肉苁蓉研究进展.天然产物研究与开发2005,17:235-241,222.

[3] 成喜雨,崔馨,倪文,刘春朝.中草药抗氧化活性研究进展.天然产物研究与开发,2006,18:214-218.

[2] 魏涛,成喜雨,杨秋婷,刘春朝.酵母诱导子对肉苁蓉细胞悬浮培养影响的研究.北京联合大学学报(自然科学版),2005,19:69-73.

[1] 王锋,成喜雨,吴天祥,刘春朝.甜高粱茎杆汁液酒精发酵及其经济可行性研究.酿酒科技,2006,146:41-44.




专著/译著

[1] 柯屾, 胡红刚, 晏琼,纪丰民, 丁克俭, 侯玲玲, 成喜雨, 田甜. 镉毒猛于虎-我国镉污染损害人体健康初探[M]。国内:华夏出版社,2013-09
[2] Cheng Xi-Yu. Two-Stage Anaerobic Fermentation for Co-Production of Hydrogen and Methane (Chapter 8 of Gas Biofuels from Waste Biomass: Principles and Advances. Editor: Liu Zhi-Dan). Nova Science Publishers, Inc. USA. 2015.
[3] Cheng Xi-Yu. ., et al. Basic Algorithms for Bioinformatics (Chapter 11 of Essential Computing Skills for Biologists. Editor: Ziling Wang, Lishu Zhang), Higher Education Press. Beijing, 2018.



专利

[1] 刘春朝,成喜雨. 一种生物、碱复合预处理秸秆纤维原料两步发酵产氢的方法. 授权专利号ZL 200910235234.3

[2] 刘春朝,成喜雨. 纤维废弃物发酵产氢气和/或甲烷的方法及其装置. 授权专利号ZL200810246603.4

[3] 刘春朝,成喜雨,王锋. 一种使用有机废弃物制备沼气的装置及其制备方法. 授权专利号ZL 200710099990.9

[4] 刘春朝,成喜雨. 一种使用生物预处理秸秆发酵制备氢气的方法. 授权专利号ZL 200710178181.7

[5] 刘春朝,刘瑞,刘英,成喜雨. 一种超声波低频-高频耦合式雾化生物反应器. 申请号:No. 201110052959.6

[6] 徐寒黎,成喜雨. 一种染色体纯合区域的检测方法、系统及电子设备.中国发明专利,申请号:No. 202310026558.6

[7] 成喜雨,晏琼等. 一种净化菌BB01及其应用. 中国发明专利,申请号:No. 202310035570.3

[8] 徐寒黎,谢玉婷,成喜雨等. 基于低深度测序数据检测基因组纯合区域的方法及系统. 中国发明专利,申请号:No. 2023104938301

[9] 成喜雨,张泽华,徐寒黎,晏琼等. 一种宏基因组数据分析系统. 中国发明专利,申请号:No. 202311286371.6

软件著作权

获奖与荣誉

2014年,入选北京交通大学首批 “青年英才” 计划

先后获得 本科优秀毕业论文、硕士优秀毕业论文、BHP Billiton-CAS (必和必拓-中科院) 奖(中科院全国25个获奖者之一)



社会兼职

国家自然科学基金通讯评审专家;北京市科学技术委员会、中关村科技园区管理委员会科技项目评审专家;SCI期刊客座编辑;Bioresource Technology, Applied Energy, Food and Chemical Toxicology
, International Journal of Hydrogen Energy, Biochemistry Engineering Journal, Energy & Fuels, Sustainable Energy Technologies and Assessments等SCI期刊审稿专家。