黄家强

基本信息

教育背景

工作经历

1993 - 1994年：华中科大同济医学院基础医学院免疫室，助教;

1997 - 1999年：北京大学医学部免疫系, 人类基因疾病中心，博士后；

1999 - 2004年：美国国家癌症研究所（NCI）, 分子免疫调节实验室， 访问学者(1999-2001), 科学家 (2001-2004, Basic Research Program, SAIC-Frederick)；

2004 - 2006年：美国约翰霍普金斯大学医学院， Faculty member，助理研究员； 

2006 -2 011年：美国Qiagen-SABiosciences，资深科学家；

2011-             ： 交通大学理学院生命科学与生物工程研究院， 教授；

2013-             ： 美国NCI， Cancer & Inflammation Program, 合作研究员

研究方向

• 生物化学与分子生物学
• 生物信息学

招生专业

• 生物学硕士

科研项目

1.    交大—诺森项目联合转化研究创新中心（S18L00290）；2018-2028；2，000万元；项目负责人。

2.    骨髓锌指1的表观调控在胃癌化疗敏感性中与金属硫蛋白2A 相互作用机制。自然科学基金面上（81872021）；67万；子课题负责。

3.    免疫力科研检测（KSL18029530）；2018-2019；3万元；项目负责人。

4.    河南“1125聚才计划”创新创业领军团队；2017-2020；300万元；领军人才，项目负责人。

5.    阿尔茨海默病检测试剂盒研发（KSL18004530）；166万；参与。            

6.    Funded in part by Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E （2013.5-  ）。

7.    Supported in part by the Intramural Research Program of the NCI, NIH （2013.5- ）。

8.    耐药结核菌检测方法的研究（KSL14010530）；2014-2017；50万元；项目负责人。

9.    恶性肿瘤发病机制及转化研究教育部重点实验室开放基金: 金属硫蛋白2A（MT2A）在胃癌中的表观调控及其功能应用研究(开放-8); 2014-2016；10万元；主持。

10.  以生物技术药为主的综合性新药研发技术大平台建设（2013ZX09301301001-005）；"重大新药创制”国家科技重大专项；1300.00万元；2013-2015 ；子课题负责人（680万元）。

11.  AMP-18在胃癌中功能机制研究及其临床应用价值（人才基金）; 2012-2015；15万元；主持

教学工作

《遗传学》（本科生);
《表观遗传学》（双语授课）（本科生);
《生命科学纵横》（本科生);
《分子细胞免疫学》（双语授课）（研究生），
 1994-1997年 华中科大同济医学院，《免疫学》（研究生），《医学免疫学》（本科生）。
 1997-1999年 北京大学, 《医学分子免疫学》（研究生），《医学免疫学》（本科生）

论文/期刊

参与著书两部，发表综述、论文50余篇; 代表性工作发表在 Cellular & Molecular Immunology、Acta Pharmaceutica Sinica B 、Clin Cancer Res, Nucleic Acids Res，EMBO J. 等顶刊杂志， 为《Nature Review of Immunology》、《Faculty of 1000》等评述。累计引用超过2300次，单篇最高引用超过200次。

Selected peer-reviewed publications: 

1. Li X, Huang J, Kang Y, Cheng X, Yan Q, Zhang L, Fan J, Xu H. Cancer Stem Cell Biomarkers in the Nervous System. Front Biosci (Landmark Ed). 2023 Dec 29;28(12):362. 
2. Chen, K., McCulloch, J., Das Neves, R. et al. The beneficial effects of commensal E. coli for colon epithelial cell recovery are related with Formyl peptide receptor 2 (Fpr2) in epithelial cells. Gut Pathog 15, 28 (2023).
3. Xu H, Lin S, Zhou Z, et al. New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine [published online ahead of print, 2023 May 17]. Cell Mol Immunol. 2023;1-38. doi:10.1038/s41423-023-01032-x.
4. Lin S, Xu H, Qin L, Pang M, Wang Z, Gu M, Zhang L, Zhao C, Hao X, Zhang Z, Ding W, Ren J, Huang J. UHRF1/DNMT1-MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer. Acta Pharm Sin B. 2023 May;13(5):2086-2106. doi: 10.1016/j.apsb.2023.02.015IF: 14.5 Q1 .
5. Chen K, Gong W, Huang J, et al. Developmental and homeostatic signaling transmitted by the G-protein coupled receptor FPR2[J]. International Immunopharmacology, 2023, 118: 110052.
6. Tian C, Liu G, Xu Y, Xia G, Zhang T, Huang J, Liu F, Li B. Beneficial effects of postoperative radiotherapy for IIIA‑N2 non‑small cell lung cancer after radical resection analysed using the propensity score‑matching method. Oncol Lett. 2023 Apr 5;25(5):205.
7. Lin S, Xu H, Pang M, Zhou X, Pan Y, Zhang L, Guan X, Wang X, Lin B, Tian R, Chen K, Zhang X, Yang Z, Ji F, Huang Y, Wei W, Gong W, Ren J, Wang JM, Guo M, Huang J. CpG Site-Specific Methylation-Modulated Divergent Expression of PRSS3 Transcript Variants Facilitates Nongenetic Intratumor Heterogeneity in Human Hepatocellular Carcinoma. Front Oncol. 2022 Apr 11;12:831268. 
8. Chen K, Gong W, Huang J, Yoshimura T, Wang JM. The potentials of short fragments of human anti-microbial peptide LL-37 as a novel therapeutic modality for diseases. Front Biosci (Landmark Ed). 2021 Nov 30;26(11):1362-1372. doi: 10.52586/5029. PMID: 34856773.
9. Shuye Lin, Cuimeng Tian, Jianhui Li, Bin Liu, Teng Ma, Keqiang Chen, Wanghua Gong, Ji Ming Wang, Jiaqiang Huang. Differential Mucin 22 Expression by Epigenetic Alterations in Human Lung Squamous Cell Carcinoma and Adenocarcinoma. Oncology Reports 45: 78, 2021.
10. Cuimeng Tian, Guimei Liu, Yongxiang Xu, Guangrong Xia, Tongmei Zhang, Jiaqiang Huang, Hui Jiang, Ji Ming Wang, Baolan Li. Postoperative radiotherapy for patients with completely resected pathological stage IIIA-N2 non-small cell lung cancer: a preferential benefit for squamous cell carcinoma. Radiol Oncol 2020. doi: 10.2478/raon-2020-0070.
11. Cuimeng Tian, Keqiang Chen, Wanghua Gong, Teizo Yoshimura, Jiaqiang Huang, Ji Ming Wang. The G-Protein Coupled Formyl Peptide Receptors and Their Role in the Progression of Digestive Tract Cancer. Technol Cancer Res Treat. 2020 Dec;19:1533033820973280.
12. Weiwei Liang, Xinjian Peng, Qingqing Li, Pingzhang Wang, Ping Lv, Quansheng Song, Shaoping She, Shiyang Huang, Keqiang Chen, Wanghua Gong, Wuxing Yuan, Vishal Thovarai, Teizo Yoshimura, Colm O'huigin, Giorgio Trinchieri, Jiaqiang Huang, Shuye Lin, Xiaohong Yao, Xiuwu Bian, Wei Kong, Jianzhong Xi, Ji Ming Wang, Ying Wang. FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis. Nat Commun. 2020 Nov 20;11(1):5912.
13. Keqiang Chen, Teizo Yoshimura, Wanghua Gong, Cuimeng Tian, Jiaqiang Huang, Giorgio Trinchieri, Ji Ming Wang. CRAMP for mouse macrophages to eliminate phagocytosed E. coli through an autophagy pathway. J Cell Sci. 2021 Mar 8;134(5):jcs252148.
14. Jie-Mei Yu, Li-Shu Zhang, Yuan-Hui Fu, Feng-Min Ji, Han-Li Xu, Jia-Qiang Huang, Xiang-Lei Peng, Yan-Peng Zheng, Ying Zhang, Jin-Sheng He. Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2. Evolutionary Bioinformatics. 2020 Oct 1; 2016:1-6.
15. Pan Y, Wang X, He Y, Lin S, Zhu M, Li Y, Wang J, Wang J, Ma X, Xu J, Yang L, Yang G, Huang J, Lu Y, Sheng J. Tumor suppressor ATP4B serve as a promising biomarker for worsening of gastric atrophy and poor differentiation. Gastric Cancer. 2021 Mar;24(2):314-326. doi: 10.1007/s10120-020-01128-7IF: 7.4 Q1 . 
16. Keqiang Chen, Teizo Yoshimura, Xiaohong Yao, Wanghua Gong, Jiaqiang Huang, Amiran K Dzutsev, John McCulloch, Colm O'hUigin, Xiu‚Äêwu Bian, Giorgio Trinchieri, Ji Ming Wang. Distinct contributions of cathelin-related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis. J Pathol. 2021 Mar;253(3):339-350.
17. Zhang M, Gao JL, Chen K, Yoshimura T, Liang W, Gong W, Li X, Huang J, McDermott DH, Murphy PM, Wang X, Wang JM: A Critical Role of Formyl Peptide Receptors in Host Defense against Escherichia coli. J Immunol. 2020 Mar 27; pii: ji1900430. doi: 10.4049/jimmunol.1900430.
18. Lin S, Zhang Y, Hu Y, Yang B, Cui J, Huang J, Wang JM, Xing R, Lu Y: Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-κB-mediated expression of CEACAM1-3S in human gastric cancer. Gastric Cancer.  2019 Sep; 22(5):941-954.
19. Lin S, Wang X, Pan Y, Tian R, Lin B, Jiang G, Chen K, He Y, Zhang L, Zhai W, Jin P, Yang L, Li G, Wu Y, Hu J, Gong W, Chang Z, Sheng JQ, Lu Y, Wang JM, Huang J. Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human Gastric Carcinogenesis by Interacting with Metallothionein 2A. Clin Cancer Res. 2019 Feb 1;25(3):1050-1062. doi: 10.1158/1078-0432.CCR-18-1281IF: 11.5 Q1 .
20. Yoshimura T, McLean MH, Dzutsev AK, Yao X, Chen K, Huang J, Gong W, Zhou J, Xiang Y, H Badger J, O'hUigin C, Thovarai V, Tessarollo L, Durum SK, Trinchieri G, Bian XW, Wang JM: The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance. J Immunol. 2018 Mar 15; 200(6):2174-2185.
21. Wang XF, Chen K, Yu Y, Xiang Y, Kim JH, Gong W, Huang J, Shi S, LiQ, Zhou M, Sayers T, Tewary P, Gao B, and Wang JM: Oncotarget. 2017; 8 (65): 109068-109078.
22. Lin B, Zhou X, Lin S, Wang X, Zhang M, Cao B, Dong Y, Yang S, Wang JM, Guo M, Huang J: Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma. J Mol Med (Berl). 2017; 95 (11): 1237–1249.
23. Jiao YY, Fu YH, Yan YF, Hua Y, Ma Y, Zhang XJ, Song JD, Peng XL, Huang J, Hong，T, He JS:  A single intranasal administration of virus-like particle vaccine induces an efficient protection for mice against human respiratory syncytial virus. Antiviral Res. 2017 Aug; 144:57-69.
24. Lin S, Lin B, Wang X, Pan Y, Xu Q, He JS, Gong W, Xing R, He Y, Guo L, Lu Y, Wang JM, Huang J: Silencing of ATP4B of ATPase H(+)/K(+) Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells. Oncol Res. 2017 Mar 13; 25(3):317-329.
25. Pan Y, Lin S, Xing R, Zhu M, Lin B, Cui J, Li W, Gao J, Shen L, Zhao Y, Guo M, Wang JM, Huang J, Lu Y. Epigenetic Upregulation of Metallothionein 2A by Diallyl Trisulfide Enhances Chemosensitivity of Human Gastric Cancer Cells to Docetaxel Through Attenuating NF-κB Activation. Antioxid Redox Signal. 2016 May 20;24(15):839-54. doi: 10.1089/ars.2014.6128IF: 6.6 Q1 . 
26. Xiang Y, Yao X, Chen K, Wang X, Zhou J, Gong W, Yoshimura T, Huang J, Wang R, Wu Y, Shi G, Bian X, Wang J: The G-protein coupled chemoattractant receptor FPR2 promotes malignant phenotype of human colon cancer cells. Am J Cancer Res. 2016; 6 (11):2599-2610.
27. Xing R, Li L, Chen L, Gao Z, Wang H, Li W, Cui J, Tian G, Liang Q, Yu J, Sung JJ, Luo G, Gao H, Xu X, Yang H, Wang J, Zhang X, Wang JM, Huang J, Yu Y, Wang J, Lu Y: Copy number variations of HLA-I and activation of NKp30 pathway determine the sensitivity of gastric cancer cells to the cytotoxicity of natural killer cells. Oncogene. 2016 May 19; 35(20):2584-91. 
28. Chen K, Xiang Y, Huang J, Gong W, Yoshimura T, Jiang Q, Tessarollo L, Le Y, Wang JM: The formylpeptide receptor 2 (Fpr2) and its endogenous ligand cathelin-related antimicrobial peptide (CRAMP) promote dendritic cell maturation. J Biol Chem. 2014 Jun 20; 289 (25): 17553-63.
29. Pan Y*, Huang J* (*Co-first author), Xing, R, Yin, X, Cui, J, Li, W. Yu, J, & Lu, Y: Metallothionein 2A inhibits NF-κB pathway activation and predicts clinical outcome segregated with TNM stage in gastric cancer patients following radical resection. J Transl Med. 2013; 11: 173.
30. Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y.:  IL-7Rapha deficiency in p53(null) mice exacerbates thymocyte telomere erosion and lymphomagenesis. Cell Death Differ. 2012; 19: 1139-51.
31. Hamano, R., Huang, J., Toshimura, T., Howard, O.M. Z., Oppenheim, J.J., Chen, X.: TNF induces co-stimulatory TNF receptor superfamily member TNFR2, 4-1BB andOX40 on CD4+FoxP3+ regulatory T cells.  Eur. J. Immunol.  2011; 41: 2010-20.
32. Tao Y, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K.: Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences.  Proc Natl Acad Sci U S A. 2011; 108: 5626-31.
33. Huang, J., Chen, K., Huang, J., Gong, W., Dunlop, N.M., Howard, O.M., Bian, X., Gao, Y., Wang, J.M.: Regulation of the leukocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation. Carcinogenesis. 2009; 30: 348-55.
34. Zhu, G., Augustine, M.M., Azuma, T., Luo, L., Yao, S., Anand, S., Rietz, A.C., Huang, J., Xu, H., Flies, A.S., Flies, S.J., Tamada, K., Colonna, M., van Deursen, J.M., Chen, L.: B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood. 2009; 113:1759-67.
35. Jiang, Q., Huang, J., Li, W.Q., Muegge, M., and Durum, S.K.: Role of the Intracellular Domain of IL-7 Receptor in T Cell Development. J. Immunol. 2007; 178: 228-234.
36. Wang, L.H., Yang, X.Y., Zhang, X., An, P., Kim, H., Huang, J., Clarke, R., Osborne, C.K.,  Inman,  J.K., Appella, E., and Farrar, L.W.: Disruption of estrogen receptor zinc finger domains and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer. Cancer Cell. 2006; 10: 487-499.
37. Huang, J., Fan, T., Yan, Q., Zhu, H., Fox, S., Issaq, H.J., Best, L., Gangi, L., Munroe, D. and Muegge, K.  Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Res. 2004; 32: 5019-5018.
38. Wang, L.H., Yang, X.Y., Zhang, X., Huang, J., Mihalic, K., Zhu, H., Xiao, W., Muegge, K., Farrar, L.W.: Transcriptional inactivation of STAT3 by PPAR gamma suppresses IL-6-responsive multiple myeloma cells. Immunity. 2004; 20: 205-18.
39. Yan, Q.*, Huang, J.* (Co-first author), Fan, T., Zhu, H., Muegge, K. Lsh, a modulator of CpG methylation, is crucial for normal histone methylation. EMBO J. 2003; 19: 5154-5162.
40. Fan, T. Yan, Q., Huang, J., Austin, S., Cho, E., Ferris, D., Muegge, K.: Lsh deficient murine embryonic fibroblasts show reduced proliferation with signs of abnormal mitosis. Cancer Res. 2003; 63: 4677-4683.
41. Khaled, A. R, Li, W. Q., Huang, J., Fry, T. J, Khaled, A. S., Mackall, C. L., Muegge, K., Young, H. A., Durum, S. K.:  Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.  Immunity. 2002; 17: 561-573.
42. Huang, J., Durum, S. K., and Muegge, K.: Cutting edge: Histone acetylation and recombination at the TCR gamma locus follows IL-7 induction. J. Immunol (cutting-edge). 2001; 167: 6073-6077.
43. Han W, Lou Y, Tang J, Zhang Y, Chen Y, Li Y, Gu W, Huang J, Gui L, Tang Y, Li F, Song Q, Di C, Wang L, Shi Q, Sun R, Xia D, Rui M, Tang J, Ma D.: Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. Biochem J. 2001 Jul 1; 357(Pt 1):127-35.
44. Huang, J. & Muegge, K.: Control of chromatin accessibility for V(D)J recombination by interleukin‑7. J. Leukoc. Biol.  2001; 69:907-11.

1. 

专著/译著

参与编写：

苏娜  沈关心 主编《抗体工程》科学出版社  1996

杨锡强 主编《儿童免疫学》 人民卫生出版社 2001

专利

授权

1. 一种复方镇痛药; Patent No: ZL 94 1 08418.3;  International paten classic No: A61K 31/5

2. Chemokine-like factors (CKLFs) with chemotactic and hematopoietic stimulating activities; International patent classic No: C07K 14/52, C12N 15/19, A61K 38/19

3. Nucleic acid molecule encoding chemokine-like factor 1 (CKLF1); United States Patent 6800454

4. MT2A基因组蛋白乙酰化修饰检测试剂盒及引物对;专利号：ZL201510598585.6

5. 一种用于肝癌诊断、化疗与预后检测的分子标记物及试剂盒；专利号：ZL201710679242.1

6. 一种用于肿瘤诊断与预后检测的分子标志物及其检测引物和试剂盒；专利号：ZL201710679293.4

7. 一种基于ATP4B基因体DNA的表观修饰检测引物对及试剂盒; 专利号：ZL201610979087.0

8. 一种用于非小细胞肺癌早期诊断、治疗与预后检测的分子分型甲基化标志物及试剂盒发明专利; 专利号：ZL 2020 1 1517819.7

提交

1. 用于胃癌诊断、化疗和预后检测的分子组合物及试剂盒; 专利申请号：S20181521。

2. 用于胃癌诊断、化疗和预后检测的分子标记物及试剂盒; 专利申请号：S20181512

3. MUC22基因启动子区相关的组蛋白修饰分析引物对及检测试剂盒；; 专利申请号：202011621103.1

4. 一种用于肿瘤分子分型、治疗用药评估的分子标志物及其检测引物和试剂盒； 专利申请号：202110016858.7

5.一种肺癌诊断、化疗或预后检测的分子标记物及其应用；专利申请号：202210132512.8。

6. 一种用于肺腺癌非创早期诊断、药效评估的分子标志物及试剂盒；专利申请号：202210133444.7

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获奖与荣誉

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