胡红刚

博士、副教授

基本信息

办公电话：010-51688577 电子邮件： hghu@bjtu.edu.cn
通讯地址： 邮编：

教育背景

教育经历

1989/07    北京大学应用化学专业                                       学士学位                                                       

2001/08    德国康斯坦茨大学生物学专业                           硕士学位                                             

2005/03    德国康斯坦茨大学分子遗传学专业                   博士学位     


工作经历

研究工作经历

1989/07 – 1993/08         铁道科学研究院金属及化学研究所                          实习生，研究实习员                         

2001/10 – 2005/03         德国康斯坦茨大学分子遗传学研究所                      科研雇员（博士生）                  

2005/04 – 2006/04         德国康斯坦茨大学分子遗传学研究所                      科研助理（博士后）                  

2006/06 –目前                北京交通大学理学院                                                   讲师，副教授


进行肿瘤细胞生物学和基因工程方面的研究工作，主要包括癌基因DEK及其他相关因子在肿瘤发生发展中的作用机制研究和抗肿瘤导向药物的研究。

  

研究方向

  • 生物化学与分子生物学
  • 细胞生物学

招生专业

  • 生物学硕士

科研项目

曾主持和参与三十余项科研项目，目前主持和参与五项科研项目

教学工作

本科教学：

有机化学，细胞生物学实验，生命科学纵横

研究生教学：

细胞生物学，细胞生物学实验

论文/期刊

      

  1.         Qian, Z., Yang J., Liu H.H., Yin Y., Hou L.L., and Hu H.G.*, The miR-1204 regulates apoptosis in NSCLC cells by targeting DEK. Folia Histochemica Et Cytobiologica, 2019. 57(2): p. 64-73.

  2.         Zhou, Q.C., Deng, X.F., Yang, J., Jiang, H., Qiao, M.X., Liu, H.H., Qian, Z., Hou, L.L., and Hu, H.G.*, Oncogene DEK is highly expressed in lung cancerous tissues and positively regulates cell proliferation as well as invasion. Oncology Letters, 2018. 15(6): p. 8573-8581.

  3.         Zeng, Y., Zhang, L., Zhu, W., He, H., Sheng, H., Tian, Q., Deng, F.Y., Zhang, L.S., Hu, H.G., and Deng, H.W., Network based subcellular proteomics in monocyte membrane revealed novel candidate genes involved in osteoporosis. Osteoporosis International, 2017. 28(10): p. 3033-3042.

  4.         Qiao, M.X., Li, C., Zhang, A.Q., Hou, L.L., Yang, J., and Hu, H.G.*, Regulation of DEK expression by AP-2 alpha and methylation level of DEK promoter in hepatocellular carcinoma. Oncology Reports, 2016. 36(4): p. 2382-2390.

  5.         Zhou, Q.C., Hu, H.G.*, and Hou, L.L., Discover, Develop & Validate - Advance and Prospect of Tumor Biomarkers. Clinical Laboratory, 2015. 61(11): p. 1589-1599.

  6.         Hou, L.L., Wang, X.Y., Zhou, Y.Q., Ma, H.B., Wang, Z.L., He, J.S., Hu, H.G., Guan, W.J., and Ma, Y.H., Inhibitory effect and mechanism of mesenchymal stem cells on liver cancer cells. Tumor Biology, 2014. 35(2): p. 1239-1250.

  7.         Li, C., Hu, H.G.*, and Hou, L.L., Ethical Controversy in Embryonic Stem Cell Research and Discussions on Public Policies. Proceedings of the 2013 International Academic Workshop on Social Science (Iaw-Sc 2013), 2013. 50: p. 950-954.

  8.        Zhang L.S., Hu H.G., Liu Y.J., Li J., Yu P., Zhang F., Yang T.L., Tian Q., Zheng Y.P., Guo Y., and Deng H.W., A follow-up association study of two genetic variants for bone mineral density variation in Caucasians. Osteoporos Int, 2012. 23(7): 1867-75.

  9.        Sun W.M., Dai X.X., Zheng Y.P., Wang J.W., Hou L.L., Du J., and Hu H.G.*, On-column refolding purification of DT389-hIL13 recombinant protein expressed in Escherichia coli. Protein Expression and Purification, 2011. 75(1): 83-88.

  10.         Hou L.L., Du J., Wang J.W., Liu Y.F., Sun W.M., Zheng Y.P., Zhang L.S., Hu H.G., Dai X.X., Guan W.J., Ma Y.H., and Hong T., Expression of IL-13R alpha 2 in liver cancer cells and its effect on targeted therapy of liver cancer. Journal of Cancer Research and Clinical Oncology, 2010. 136(6): 839-846.

  11.         Fu Y.H., Lv R.J., Jin L.R., Lu Q.A., Shao X.Q., He J.S., Wu L.W., Zhang L.S., and Hu H.G., Association of apolipoprotein E polymorphisms with temporal lobe epilepsy in a Chinese Han population. Epilepsy Research, 2010. 91(2-3): 253-259.

  12.         Hua Y., Hu H.G.*, Peng X.L., Progress in studies on the DEK protein and its involvement in cellular apoptosis. Sci China Ser C-Life Sci, 2009, 52(7): 637-642

  13.         Hu H.G., Baack M., and Knippers R., Proteins of the origin recognition complex (ORC) and DNA topoisomerases on mammalian chromatin. BMC Mol Biol, 2009, 10: 36

  14.         Hu H.G., Scholten I., Gruss C., and Knippers R., The distribution of the DEK protein in mammalian chromatin. Biochem Biophys Res Commun, 2007, 358: 1008-14.

  15.         Hu H.G., Illges H., Gruss C., and Knippers R., Distribution of the chromatin protein DEK distinguishes active and inactive CD21/CR2 gene in pre- and mature B lymphocytes. Int Immunol, 2005, 17: 789-96.

  16.        Waldmann T., Scholten, I.  Kappes F., Hu H.G., and Knippers R., The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin. Gene, 2004, 343: 1-9

  17.        郭海红，杨辛，郭芳，胡红刚*  DEK蛋白的真核表达纯化及其活性检测 中国生物工程杂志，2011, 31(12): 1-9

  18.        华颖，胡红刚*，彭向雷  DEK蛋白C末端DNA结合域的原核表达、纯化及其与DNA的结合活性 中国生物工程杂志, 2009, 29(8): 14-18

  19.        胡红刚，陈珊珊. 表皮生长因子受体III型变异体（EGFRvIII）多克隆抗体的制备及其特异性. 北京交通大学学报, 2009, 33(3): 99-102


专著/译著

  1. 柯屾,胡红刚,晏琼,纪丰民,丁克俭,侯玲玲,成喜雨,田甜. 镉毒猛于虎-我国镉污染损害人体健康初探. 华夏出版社, 2013.09

专利

软件著作权

获奖与荣誉

社会兼职